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The relationship between early reversibility test and maximal inspiratory pressure in patients with airway obstruction

Maximal inspiratory pressure (MIP) is a marker for assessing the degree of respiratory muscle dysfunction. Muscle dysfunction represents a pathophysiological feature of chronic obstructive pulmonary disease. We aimed to determinate the MIP value in patients with airway obstruction, to evaluate the c...

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Autores principales: Ozkaya, Sevket, Dirican, Adem, Kaya, Sule Ozbay, Karanfil, Rabia C, Bayrak, Merve G, Bostancı, Ozgür, Ece, Ferah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015719/
https://www.ncbi.nlm.nih.gov/pubmed/24833899
http://dx.doi.org/10.2147/COPD.S58584
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author Ozkaya, Sevket
Dirican, Adem
Kaya, Sule Ozbay
Karanfil, Rabia C
Bayrak, Merve G
Bostancı, Ozgür
Ece, Ferah
author_facet Ozkaya, Sevket
Dirican, Adem
Kaya, Sule Ozbay
Karanfil, Rabia C
Bayrak, Merve G
Bostancı, Ozgür
Ece, Ferah
author_sort Ozkaya, Sevket
collection PubMed
description Maximal inspiratory pressure (MIP) is a marker for assessing the degree of respiratory muscle dysfunction. Muscle dysfunction represents a pathophysiological feature of chronic obstructive pulmonary disease. We aimed to determinate the MIP value in patients with airway obstruction, to evaluate the change in MIP with bronchodilator drug, and to show the relationship between the changes in MIP and disease characteristics. We evaluated 21 patients with airway obstruction at the Department of Pulmonary Medicine, Samsun Medicalpark Hospital, Samsun, Turkey. We performed pulmonary function tests, measurement of MIP values, and reversibility tests with salbutamol. The baseline spirometry results were: mean forced vital capacity (FVC), 3,017±1,020 mL and 75.8%±20.8%; mean forced expiratory volume in 1 second (FEV(1)), 1,892±701 mL and 59.2%±18.2%; FEV(1)/FVC, 62.9%±5.5%; peak expiratory flow, 53%±19%. The pre-bronchodilator MIP value was 62.1±36.9 cmH(2)O. The reversibility test was found to be positive in 61.9% of patients with salbutamol. The absolute change and percentage of change in FEV(1) were 318±223 mL and 19.8%±16.7%, respectively. The MIP value was increased by 5.5 cmH(2)O (8.8%) and was 67.7±30.3 cmH(2)O after bronchodilation. There was no significant relationship between age, FEV(1), reversibility, and change in MIP with bronchodilator. However, the increase in MIP with bronchodilator drug was higher in patients with low body mass index (<25 kg/m(2)). We noted a 13.1% increase in FVC, a 19.8% increase in FEV(1), a 20.2% increase in peak expiratory flow, and an 8.8% increase in MIP with salbutamol. In conclusion; MIP increases with bronchodilator therapy, regardless of changes in lung function, in patients with airway obstruction. The reversibilty test can be used to evaluate change in MIP with salbutamol.
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spelling pubmed-40157192014-05-15 The relationship between early reversibility test and maximal inspiratory pressure in patients with airway obstruction Ozkaya, Sevket Dirican, Adem Kaya, Sule Ozbay Karanfil, Rabia C Bayrak, Merve G Bostancı, Ozgür Ece, Ferah Int J Chron Obstruct Pulmon Dis Original Research Maximal inspiratory pressure (MIP) is a marker for assessing the degree of respiratory muscle dysfunction. Muscle dysfunction represents a pathophysiological feature of chronic obstructive pulmonary disease. We aimed to determinate the MIP value in patients with airway obstruction, to evaluate the change in MIP with bronchodilator drug, and to show the relationship between the changes in MIP and disease characteristics. We evaluated 21 patients with airway obstruction at the Department of Pulmonary Medicine, Samsun Medicalpark Hospital, Samsun, Turkey. We performed pulmonary function tests, measurement of MIP values, and reversibility tests with salbutamol. The baseline spirometry results were: mean forced vital capacity (FVC), 3,017±1,020 mL and 75.8%±20.8%; mean forced expiratory volume in 1 second (FEV(1)), 1,892±701 mL and 59.2%±18.2%; FEV(1)/FVC, 62.9%±5.5%; peak expiratory flow, 53%±19%. The pre-bronchodilator MIP value was 62.1±36.9 cmH(2)O. The reversibility test was found to be positive in 61.9% of patients with salbutamol. The absolute change and percentage of change in FEV(1) were 318±223 mL and 19.8%±16.7%, respectively. The MIP value was increased by 5.5 cmH(2)O (8.8%) and was 67.7±30.3 cmH(2)O after bronchodilation. There was no significant relationship between age, FEV(1), reversibility, and change in MIP with bronchodilator. However, the increase in MIP with bronchodilator drug was higher in patients with low body mass index (<25 kg/m(2)). We noted a 13.1% increase in FVC, a 19.8% increase in FEV(1), a 20.2% increase in peak expiratory flow, and an 8.8% increase in MIP with salbutamol. In conclusion; MIP increases with bronchodilator therapy, regardless of changes in lung function, in patients with airway obstruction. The reversibilty test can be used to evaluate change in MIP with salbutamol. Dove Medical Press 2014-05-05 /pmc/articles/PMC4015719/ /pubmed/24833899 http://dx.doi.org/10.2147/COPD.S58584 Text en © 2014 Ozkaya et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Ozkaya, Sevket
Dirican, Adem
Kaya, Sule Ozbay
Karanfil, Rabia C
Bayrak, Merve G
Bostancı, Ozgür
Ece, Ferah
The relationship between early reversibility test and maximal inspiratory pressure in patients with airway obstruction
title The relationship between early reversibility test and maximal inspiratory pressure in patients with airway obstruction
title_full The relationship between early reversibility test and maximal inspiratory pressure in patients with airway obstruction
title_fullStr The relationship between early reversibility test and maximal inspiratory pressure in patients with airway obstruction
title_full_unstemmed The relationship between early reversibility test and maximal inspiratory pressure in patients with airway obstruction
title_short The relationship between early reversibility test and maximal inspiratory pressure in patients with airway obstruction
title_sort relationship between early reversibility test and maximal inspiratory pressure in patients with airway obstruction
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015719/
https://www.ncbi.nlm.nih.gov/pubmed/24833899
http://dx.doi.org/10.2147/COPD.S58584
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