Oncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survival

BACKGROUND: The transcription factor Nrf2 is a key regulator of the cellular antioxidant response, and its activation by chemoprotective agents has been proposed as a potential strategy to prevent cancer. However, activating mutations in the Nrf2 pathway have been found to promote tumorigenesis in c...

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Detalles Bibliográficos
Autores principales: Funes, Juan M, Henderson, Stephen, Kaufman, Rachel, Flanagan, James M, Robson, Mathew, Pedley, Barbara, Moncada, Salvador, Boshoff, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015761/
https://www.ncbi.nlm.nih.gov/pubmed/24491031
http://dx.doi.org/10.1186/1476-4598-13-20

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