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Generation of superoxide anion radicals and platelet glutathione peroxidase activity in patients with schizophrenia

Blood platelets are considered to be a peripheral marker in schizophrenia and other psychiatric disorders. Oxidative stress in schizophrenia may be responsible for changes in platelet metabolism and function; therefore, the aim of this study was to examine and compare the generation of superoxide an...

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Autores principales: Dietrich-Muszalska, Anna, Kwiatkowska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015795/
https://www.ncbi.nlm.nih.gov/pubmed/24833903
http://dx.doi.org/10.2147/NDT.S60034
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author Dietrich-Muszalska, Anna
Kwiatkowska, Anna
author_facet Dietrich-Muszalska, Anna
Kwiatkowska, Anna
author_sort Dietrich-Muszalska, Anna
collection PubMed
description Blood platelets are considered to be a peripheral marker in schizophrenia and other psychiatric disorders. Oxidative stress in schizophrenia may be responsible for changes in platelet metabolism and function; therefore, the aim of this study was to examine and compare the generation of superoxide anions and activity of an antioxidant enzyme (glutathione peroxidase [GPx]) in blood platelets in patients with schizophrenia and healthy subjects. The level of superoxide anions generated in platelets after thrombin and platelet-activating factor stimulation and activity of GPx in patients with schizophrenia and healthy volunteers was estimated. The results obtained from the study indicate that the generation of superoxide anions in platelets as a response of platelets in patients with schizophrenia to such activating factors as thrombin or platelet-activating factor is higher than in the response of platelets of healthy subjects. In platelets from schizophrenic patients, suppressed GPx activity of about 67% was observed.
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spelling pubmed-40157952014-05-15 Generation of superoxide anion radicals and platelet glutathione peroxidase activity in patients with schizophrenia Dietrich-Muszalska, Anna Kwiatkowska, Anna Neuropsychiatr Dis Treat Original Research Blood platelets are considered to be a peripheral marker in schizophrenia and other psychiatric disorders. Oxidative stress in schizophrenia may be responsible for changes in platelet metabolism and function; therefore, the aim of this study was to examine and compare the generation of superoxide anions and activity of an antioxidant enzyme (glutathione peroxidase [GPx]) in blood platelets in patients with schizophrenia and healthy subjects. The level of superoxide anions generated in platelets after thrombin and platelet-activating factor stimulation and activity of GPx in patients with schizophrenia and healthy volunteers was estimated. The results obtained from the study indicate that the generation of superoxide anions in platelets as a response of platelets in patients with schizophrenia to such activating factors as thrombin or platelet-activating factor is higher than in the response of platelets of healthy subjects. In platelets from schizophrenic patients, suppressed GPx activity of about 67% was observed. Dove Medical Press 2014-05-05 /pmc/articles/PMC4015795/ /pubmed/24833903 http://dx.doi.org/10.2147/NDT.S60034 Text en © 2014 Dietrich-Muszalska and Kwiatkowska. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Dietrich-Muszalska, Anna
Kwiatkowska, Anna
Generation of superoxide anion radicals and platelet glutathione peroxidase activity in patients with schizophrenia
title Generation of superoxide anion radicals and platelet glutathione peroxidase activity in patients with schizophrenia
title_full Generation of superoxide anion radicals and platelet glutathione peroxidase activity in patients with schizophrenia
title_fullStr Generation of superoxide anion radicals and platelet glutathione peroxidase activity in patients with schizophrenia
title_full_unstemmed Generation of superoxide anion radicals and platelet glutathione peroxidase activity in patients with schizophrenia
title_short Generation of superoxide anion radicals and platelet glutathione peroxidase activity in patients with schizophrenia
title_sort generation of superoxide anion radicals and platelet glutathione peroxidase activity in patients with schizophrenia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015795/
https://www.ncbi.nlm.nih.gov/pubmed/24833903
http://dx.doi.org/10.2147/NDT.S60034
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