Cargando…

Caveolin-1 in renal cell carcinoma promotes tumour cell invasion, and in co-operation with pERK predicts metastases in patients with clinically confined disease

BACKGROUND: Up to 40% of patients initially diagnosed with clinically-confined renal cell carcinoma (RCC) and who undergo curative surgery will nevertheless relapse with metastatic disease (mRCC) associated with poor long term survival. The discovery of novel prognostic/predictive biomarkers and dru...

Descripción completa

Detalles Bibliográficos
Autores principales:	Campbell, Lee, Al-Jayyoussi, Ghaith, Gutteridge, Robert, Gumbleton, Nigel, Griffiths, Rosie, Gumbleton, Simon, Smith, Mathew W, Griffiths, David FR, Gumbleton, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015803/ https://www.ncbi.nlm.nih.gov/pubmed/24119769 http://dx.doi.org/10.1186/1479-5876-11-255

Ejemplares similares

Caveolin-1 overexpression predicts poor disease-free survival of patients with clinically confined renal cell carcinoma
por: Campbell, L, et al.
Publicado: (2003)

Combined expression of caveolin-1 and an activated AKT/mTOR pathway predicts reduced disease-free survival in clinically confined renal cell carcinoma
por: Campbell, L, et al.
Publicado: (2008)

Endocytic Uptake, Transport and Macromolecular Interactions of Anionic PAMAM Dendrimers within Lung Tissue
por: Morris, Christopher J., et al.
Publicado: (2017)

Caveolin-1, a Key Mediator Across Multiple Pathways in Glioblastoma and an Independent Negative Biomarker of Patient Survival
por: Moriconi, Chiara, et al.
Publicado: (2021)

Role of inositol phospholipid signaling in natural killer cell biology
por: Gumbleton, Matthew, et al.
Publicado: (2013)

TTF-1 and immune checkpoint therapy in non-small cell lung cancer
por: Gumbleton, Matthew, et al.
Publicado: (2023)

Satellitosis, a Crosstalk between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour
por: Civita, Prospero, et al.
Publicado: (2020)

Destabilization of α-Helical Structure in Solution Improves Bactericidal Activity of Antimicrobial Peptides: Opposite Effects on Bacterial and Viral Targets
por: Ulaeto, David O., et al.
Publicado: (2016)

Humidified Warmed CO(2) Treatment Therapy Strategies Can Save Lives With Mitigation and Suppression of SARS-CoV-2 Infection: An Evidence Review
por: El-Betany, Alaa M. M., et al.
Publicado: (2020)

The Differential Absorption of a Series of P-Glycoprotein Substrates in Isolated Perfused Lungs from Mdr1a/1b Genetic Knockout Mice can be Attributed to Distinct Physico-Chemical Properties: an Insight into Predicting Transporter-Mediated, Pulmonary Specific Disposition
por: Price, Daniel F., et al.
Publicado: (2017)

SHIPi Enhances Autologous and Allogeneic Hematopoietic Stem Cell Transplantation
por: Fernandes, Sandra, et al.
Publicado: (2015)

Oral Immunogenicity in Mice and Sows of Enterotoxigenic Escherichia Coli Outer-Membrane Vesicles Incorporated into Zein-Based Nanoparticles
por: Matías, Jose, et al.
Publicado: (2019)

1283. High Dose Minocycline for the Treatment of Acinetobacter Infections
por: Herbin, Shelbye R, et al.
Publicado: (2021)

Modulation of the fate of zein nanoparticles by their coating with a Gantrez® AN-thiamine polymer conjugate
por: Inchaurraga, Laura, et al.
Publicado: (2019)

Quantifying the effects of antibiotic treatment on the extracellular polymer network of antimicrobial resistant and sensitive biofilms using multiple particle tracking
por: Powell, Lydia C., et al.
Publicado: (2021)

A phase I open-label study of the safety and efficacy of apatinib (rivoceranib) administered to patients with advanced malignancies to improve sensitivity to pembrolizumab in the second- or later-line setting (APPEASE)
por: Gumbleton, Matthew, et al.
Publicado: (2023)

Poly(ethylene glycol) based nanotubes for tuneable drug delivery to glioblastoma multiforme
por: Alghamdi, Majed, et al.
Publicado: (2020)

The Neurogenic Potential of Astrocytes Is Regulated by Inflammatory Signals
por: Michelucci, Alessandro, et al.
Publicado: (2015)

GAMBIT (Genomic Approximation Method for Bacterial Identification and Tracking): A methodology to rapidly leverage whole genome sequencing of bacterial isolates for clinical identification
por: Lumpe, Jared, et al.
Publicado: (2023)

ERK/pERK expression and B-raf mutations in colon adenocarcinomas: correlation with clinicopathological characteristics
por: Levidou, Georgia, et al.
Publicado: (2012)

Stromal Caveolin-1 and Caveolin-2 Expression in Primary Tumors and Lymph Node Metastases
por: Gerstenberger, Wladimir, et al.
Publicado: (2018)

A NANOG‐pERK reciprocal regulatory circuit regulates Nanog autoregulation and ERK signaling dynamics
por: Kale, Hanuman T, et al.
Publicado: (2022)

Doxorubicin Induces Cytotoxicity through Upregulation of pERK–Dependent ATF3
por: Park, Eun-Jung, et al.
Publicado: (2012)

Neurochemical characterization of pERK-expressing spinal neurons in histamine-induced itch
por: Jiang, Guan-Yu, et al.
Publicado: (2015)

Enhancement of Anxiety and Modulation of TH and pERK Expressions in Amygdala by Repeated Injections of Corticosterone
por: Lim, Heena, et al.
Publicado: (2012)

Using pERK immunostaining to quantify neuronal activity induced by stress in zebrafish larvae
por: Corradi, Laura, et al.
Publicado: (2022)

Cell-Specific Dual Role of Caveolin-1 in Pulmonary Hypertension
por: Mathew, Rajamma
Publicado: (2011)

pERK-dependent defective TCR-mediated activation of CD4(+) T cells in end-stage renal disease patients
por: Huang, Ling, et al.
Publicado: (2017)

Interaction of Nck1 and PERK phosphorylated at Y(561) negatively modulates PERK activity and PERK regulation of pancreatic β-cell proinsulin content
por: Yamani, Lama, et al.
Publicado: (2014)

A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2
por: Kwon, Hayeong, et al.
Publicado: (2011)

pERK/pAkt phenotyping in circulating tumor cells as a biomarker for sorafenib efficacy in patients with advanced hepatocellular carcinoma
por: Li, Jun, et al.
Publicado: (2015)

Upregulation of pERK and c-JUN by γ-tocotrienol and not α-tocopherol are essential to the differential effect on apoptosis in prostate cancer cells
por: Moore, Christine, et al.
Publicado: (2020)

EGR1 upregulation following Venezuelan equine encephalitis virus infection is regulated by ERK and PERK pathways contributing to cell death
por: Dahal, Bibha, et al.
Publicado: (2020)

Modulation of RECK levels in Xenopus A6 cells: effects on MT1-MMP, MMP-2 and pERK levels
por: Willson, Jessica A., et al.
Publicado: (2019)

Metastasizing capacity of tumour cells from spontaneous metastases of transplanted murine tumours.
por: Giavazzi, R., et al.
Publicado: (1980)

Glycosylation PERKs
por: Williams, Ruth
Publicado: (2007)

Imatinib Mesylate Reduces Neurotrophic Factors and pERK and pAKT Expression in Urinary Bladder of Female Mice With Cyclophosphamide-Induced Cystitis
por: Perkins, Megan, et al.
Publicado: (2022)

Histology-dependent prognostic role of pERK and p53 protein levels in early-stage non-small cell lung cancer
por: Quintanal-Villalonga, Álvaro, et al.
Publicado: (2018)

The Histone Deacetylase Inhibitor JAHA Down-Regulates pERK and Global DNA Methylation in MDA-MB231 Breast Cancer Cells
por: Librizzi, Mariangela, et al.
Publicado: (2015)

Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells
por: Boothe, Tobias, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_nrb3iv2q8g459440s9trurfph0