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Lovastatin improves impaired synaptic plasticity and phasic alertness in patients with neurofibromatosis type 1
BACKGROUND: Neurofibromatosis type 1 (NF1) is one of the most common genetic disorders causing learning disabilities by mutations in the neurofibromin gene, an important inhibitor of the RAS pathway. In a mouse model of NF1, a loss of function mutation of the neurofibromin gene resulted in increased...
Autores principales: | Mainberger, Florian, Jung, Nikolai H, Zenker, Martin, Wahlländer, Ute, Freudenberg, Leonie, Langer, Susanne, Berweck, Steffen, Winkler, Tobias, Straube, Andreas, Heinen, Florian, Granström, Sofia, Mautner, Victor-Felix, Lidzba, Karen, Mall, Volker |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015838/ https://www.ncbi.nlm.nih.gov/pubmed/24088225 http://dx.doi.org/10.1186/1471-2377-13-131 |
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