Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer

BACKGROUND: Drug resistance is a significant problem in the treatment of ovarian cancer and can be caused by multiple mechanisms. Inhibition of apoptosis by the inhibitor of apoptosis proteins (IAPs) represents one such mechanism, and can be overcome by a mitochondrial protein called second mitochon...

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Detalles Bibliográficos
Autores principales: Garg, Gunjal, Vangveravong, Suwanna, Zeng, Chenbo, Collins, Lynne, Hornick, Mary, Hashim, Yassar, Piwnica-Worms, David, Powell, Matthew A, Mutch, David G, Mach, Robert H, Hawkins, William G, Spitzer, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015918/
https://www.ncbi.nlm.nih.gov/pubmed/24602489
http://dx.doi.org/10.1186/1476-4598-13-50

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