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Tacrolimus Increases Nox4 Expression in Human Renal Fibroblasts and Induces Fibrosis-Related Genes by Aberrant TGF-Beta Receptor Signalling

Chronic nephrotoxicity of immunosuppressives is one of the main limiting factors in the long-term outcome of kidney transplants, leading to tissue fibrosis and ultimate organ failure. The cytokine TGF-β is considered a key factor in this process. In the human renal fibroblast cell line TK-173, the m...

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Detalles Bibliográficos
Autores principales:	Kern, Georg, Mair, Sabine M., Noppert, Susie-Jane, Jennings, Paul, Schramek, Herbert, Rudnicki, Michael, Mueller, Gerhard A., Mayer, Gert, Koppelstaetter, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015940/ https://www.ncbi.nlm.nih.gov/pubmed/24816588 http://dx.doi.org/10.1371/journal.pone.0096377

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