Exometabolome analysis reveals hypoxia at the up-scaling of a Saccharomyces cerevisiae high-cell density fed-batch biopharmaceutical process

BACKGROUND: Scale-up to industrial production level of a fermentation process occurs after optimization at small scale, a critical transition for successful technology transfer and commercialization of a product of interest. At the large scale a number of important bioprocess engineering problems ar...

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Detalles Bibliográficos
Autores principales: Fu, Zhibiao, Verderame, Thomas D, Leighton, Julie M, Sampey, Brante P, Appelbaum, Edward R, Patel, Pramatesh S, Aon, Juan C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016033/
https://www.ncbi.nlm.nih.gov/pubmed/24593159
http://dx.doi.org/10.1186/1475-2859-13-32

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