Cargando…
Characterization of Pore Structure in Biologically Functional Poly(2-Hydroxyethyl Methacrylate) - Poly(Ethylene Glycol) Diacrylate (PHEMA-PEGDA)
A copolymer composed of poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(ethylene glycol) diacrylate (PEGDA) (PHEMA-PEGDA) is structurally versatile. Its structure can be adjusted using the following porogens: water, sucrose, and benzyl alcohol. Using phase separation technique, a variety of surfa...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016039/ https://www.ncbi.nlm.nih.gov/pubmed/24816589 http://dx.doi.org/10.1371/journal.pone.0096709 |
_version_ | 1782315453456056320 |
---|---|
author | Zellander, Amelia Zhao, Chenlin Kotecha, Mrignayani Gemeinhart, Richard Wardlow, Melissa Abiade, Jeremiah Cho, Michael |
author_facet | Zellander, Amelia Zhao, Chenlin Kotecha, Mrignayani Gemeinhart, Richard Wardlow, Melissa Abiade, Jeremiah Cho, Michael |
author_sort | Zellander, Amelia |
collection | PubMed |
description | A copolymer composed of poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(ethylene glycol) diacrylate (PEGDA) (PHEMA-PEGDA) is structurally versatile. Its structure can be adjusted using the following porogens: water, sucrose, and benzyl alcohol. Using phase separation technique, a variety of surface architectures and pore morphologies were developed by adjusting porogen volume and type. The water and sucrose porogens were effective in creating porous and cytocompatible PHEMA-PEGDA scaffolds. When coated with collagen, the PHEMA-PEGDA scaffolds accommodated cell migration. The PHEMA-PEGDA scaffolds are easy to produce, non-toxic, and mechanically stable enough to resist fracture during routine handling. The PHEMA-PEGDA structures presented in this study may expedite the current research effort to engineer tissue scaffolds that provide both structural stability and biological activity. |
format | Online Article Text |
id | pubmed-4016039 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-40160392014-05-14 Characterization of Pore Structure in Biologically Functional Poly(2-Hydroxyethyl Methacrylate) - Poly(Ethylene Glycol) Diacrylate (PHEMA-PEGDA) Zellander, Amelia Zhao, Chenlin Kotecha, Mrignayani Gemeinhart, Richard Wardlow, Melissa Abiade, Jeremiah Cho, Michael PLoS One Research Article A copolymer composed of poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(ethylene glycol) diacrylate (PEGDA) (PHEMA-PEGDA) is structurally versatile. Its structure can be adjusted using the following porogens: water, sucrose, and benzyl alcohol. Using phase separation technique, a variety of surface architectures and pore morphologies were developed by adjusting porogen volume and type. The water and sucrose porogens were effective in creating porous and cytocompatible PHEMA-PEGDA scaffolds. When coated with collagen, the PHEMA-PEGDA scaffolds accommodated cell migration. The PHEMA-PEGDA scaffolds are easy to produce, non-toxic, and mechanically stable enough to resist fracture during routine handling. The PHEMA-PEGDA structures presented in this study may expedite the current research effort to engineer tissue scaffolds that provide both structural stability and biological activity. Public Library of Science 2014-05-09 /pmc/articles/PMC4016039/ /pubmed/24816589 http://dx.doi.org/10.1371/journal.pone.0096709 Text en © 2014 Zellander et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Zellander, Amelia Zhao, Chenlin Kotecha, Mrignayani Gemeinhart, Richard Wardlow, Melissa Abiade, Jeremiah Cho, Michael Characterization of Pore Structure in Biologically Functional Poly(2-Hydroxyethyl Methacrylate) - Poly(Ethylene Glycol) Diacrylate (PHEMA-PEGDA) |
title | Characterization of Pore Structure in Biologically Functional Poly(2-Hydroxyethyl Methacrylate) - Poly(Ethylene Glycol) Diacrylate (PHEMA-PEGDA) |
title_full | Characterization of Pore Structure in Biologically Functional Poly(2-Hydroxyethyl Methacrylate) - Poly(Ethylene Glycol) Diacrylate (PHEMA-PEGDA) |
title_fullStr | Characterization of Pore Structure in Biologically Functional Poly(2-Hydroxyethyl Methacrylate) - Poly(Ethylene Glycol) Diacrylate (PHEMA-PEGDA) |
title_full_unstemmed | Characterization of Pore Structure in Biologically Functional Poly(2-Hydroxyethyl Methacrylate) - Poly(Ethylene Glycol) Diacrylate (PHEMA-PEGDA) |
title_short | Characterization of Pore Structure in Biologically Functional Poly(2-Hydroxyethyl Methacrylate) - Poly(Ethylene Glycol) Diacrylate (PHEMA-PEGDA) |
title_sort | characterization of pore structure in biologically functional poly(2-hydroxyethyl methacrylate) - poly(ethylene glycol) diacrylate (phema-pegda) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016039/ https://www.ncbi.nlm.nih.gov/pubmed/24816589 http://dx.doi.org/10.1371/journal.pone.0096709 |
work_keys_str_mv | AT zellanderamelia characterizationofporestructureinbiologicallyfunctionalpoly2hydroxyethylmethacrylatepolyethyleneglycoldiacrylatephemapegda AT zhaochenlin characterizationofporestructureinbiologicallyfunctionalpoly2hydroxyethylmethacrylatepolyethyleneglycoldiacrylatephemapegda AT kotechamrignayani characterizationofporestructureinbiologicallyfunctionalpoly2hydroxyethylmethacrylatepolyethyleneglycoldiacrylatephemapegda AT gemeinhartrichard characterizationofporestructureinbiologicallyfunctionalpoly2hydroxyethylmethacrylatepolyethyleneglycoldiacrylatephemapegda AT wardlowmelissa characterizationofporestructureinbiologicallyfunctionalpoly2hydroxyethylmethacrylatepolyethyleneglycoldiacrylatephemapegda AT abiadejeremiah characterizationofporestructureinbiologicallyfunctionalpoly2hydroxyethylmethacrylatepolyethyleneglycoldiacrylatephemapegda AT chomichael characterizationofporestructureinbiologicallyfunctionalpoly2hydroxyethylmethacrylatepolyethyleneglycoldiacrylatephemapegda |