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Characterization of Pore Structure in Biologically Functional Poly(2-Hydroxyethyl Methacrylate) - Poly(Ethylene Glycol) Diacrylate (PHEMA-PEGDA)

A copolymer composed of poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(ethylene glycol) diacrylate (PEGDA) (PHEMA-PEGDA) is structurally versatile. Its structure can be adjusted using the following porogens: water, sucrose, and benzyl alcohol. Using phase separation technique, a variety of surfa...

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Detalles Bibliográficos
Autores principales: Zellander, Amelia, Zhao, Chenlin, Kotecha, Mrignayani, Gemeinhart, Richard, Wardlow, Melissa, Abiade, Jeremiah, Cho, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016039/
https://www.ncbi.nlm.nih.gov/pubmed/24816589
http://dx.doi.org/10.1371/journal.pone.0096709
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author Zellander, Amelia
Zhao, Chenlin
Kotecha, Mrignayani
Gemeinhart, Richard
Wardlow, Melissa
Abiade, Jeremiah
Cho, Michael
author_facet Zellander, Amelia
Zhao, Chenlin
Kotecha, Mrignayani
Gemeinhart, Richard
Wardlow, Melissa
Abiade, Jeremiah
Cho, Michael
author_sort Zellander, Amelia
collection PubMed
description A copolymer composed of poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(ethylene glycol) diacrylate (PEGDA) (PHEMA-PEGDA) is structurally versatile. Its structure can be adjusted using the following porogens: water, sucrose, and benzyl alcohol. Using phase separation technique, a variety of surface architectures and pore morphologies were developed by adjusting porogen volume and type. The water and sucrose porogens were effective in creating porous and cytocompatible PHEMA-PEGDA scaffolds. When coated with collagen, the PHEMA-PEGDA scaffolds accommodated cell migration. The PHEMA-PEGDA scaffolds are easy to produce, non-toxic, and mechanically stable enough to resist fracture during routine handling. The PHEMA-PEGDA structures presented in this study may expedite the current research effort to engineer tissue scaffolds that provide both structural stability and biological activity.
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spelling pubmed-40160392014-05-14 Characterization of Pore Structure in Biologically Functional Poly(2-Hydroxyethyl Methacrylate) - Poly(Ethylene Glycol) Diacrylate (PHEMA-PEGDA) Zellander, Amelia Zhao, Chenlin Kotecha, Mrignayani Gemeinhart, Richard Wardlow, Melissa Abiade, Jeremiah Cho, Michael PLoS One Research Article A copolymer composed of poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(ethylene glycol) diacrylate (PEGDA) (PHEMA-PEGDA) is structurally versatile. Its structure can be adjusted using the following porogens: water, sucrose, and benzyl alcohol. Using phase separation technique, a variety of surface architectures and pore morphologies were developed by adjusting porogen volume and type. The water and sucrose porogens were effective in creating porous and cytocompatible PHEMA-PEGDA scaffolds. When coated with collagen, the PHEMA-PEGDA scaffolds accommodated cell migration. The PHEMA-PEGDA scaffolds are easy to produce, non-toxic, and mechanically stable enough to resist fracture during routine handling. The PHEMA-PEGDA structures presented in this study may expedite the current research effort to engineer tissue scaffolds that provide both structural stability and biological activity. Public Library of Science 2014-05-09 /pmc/articles/PMC4016039/ /pubmed/24816589 http://dx.doi.org/10.1371/journal.pone.0096709 Text en © 2014 Zellander et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zellander, Amelia
Zhao, Chenlin
Kotecha, Mrignayani
Gemeinhart, Richard
Wardlow, Melissa
Abiade, Jeremiah
Cho, Michael
Characterization of Pore Structure in Biologically Functional Poly(2-Hydroxyethyl Methacrylate) - Poly(Ethylene Glycol) Diacrylate (PHEMA-PEGDA)
title Characterization of Pore Structure in Biologically Functional Poly(2-Hydroxyethyl Methacrylate) - Poly(Ethylene Glycol) Diacrylate (PHEMA-PEGDA)
title_full Characterization of Pore Structure in Biologically Functional Poly(2-Hydroxyethyl Methacrylate) - Poly(Ethylene Glycol) Diacrylate (PHEMA-PEGDA)
title_fullStr Characterization of Pore Structure in Biologically Functional Poly(2-Hydroxyethyl Methacrylate) - Poly(Ethylene Glycol) Diacrylate (PHEMA-PEGDA)
title_full_unstemmed Characterization of Pore Structure in Biologically Functional Poly(2-Hydroxyethyl Methacrylate) - Poly(Ethylene Glycol) Diacrylate (PHEMA-PEGDA)
title_short Characterization of Pore Structure in Biologically Functional Poly(2-Hydroxyethyl Methacrylate) - Poly(Ethylene Glycol) Diacrylate (PHEMA-PEGDA)
title_sort characterization of pore structure in biologically functional poly(2-hydroxyethyl methacrylate) - poly(ethylene glycol) diacrylate (phema-pegda)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016039/
https://www.ncbi.nlm.nih.gov/pubmed/24816589
http://dx.doi.org/10.1371/journal.pone.0096709
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