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Serologic autoimmunologic parameters in women with primary ovarian insufficiency

BACKGROUND: Primary ovarian insufficiency (POI) is heterogeneous disease defined by amenorrhea or premature depletion of ovarian follicles before the age of 40 years. The etiology of POI is still unclear. The purpose of this study is to evaluate whether women with POI have an elevated serum levels o...

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Autores principales: Zhen, Xiumei, Qiao, Jie, Li, Rong, Wang, Lina, Liu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016123/
https://www.ncbi.nlm.nih.gov/pubmed/24606591
http://dx.doi.org/10.1186/1471-2172-15-11
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author Zhen, Xiumei
Qiao, Jie
Li, Rong
Wang, Lina
Liu, Ping
author_facet Zhen, Xiumei
Qiao, Jie
Li, Rong
Wang, Lina
Liu, Ping
author_sort Zhen, Xiumei
collection PubMed
description BACKGROUND: Primary ovarian insufficiency (POI) is heterogeneous disease defined by amenorrhea or premature depletion of ovarian follicles before the age of 40 years. The etiology of POI is still unclear. The purpose of this study is to evaluate whether women with POI have an elevated serum levels of autoimmunologic parameters. METHODS: The serum from peripheral blood samples which come from 96 POI patients and 100 age-matched health women were analyzed for a series of autoimmune antibodies using protein microarray. The antibodies to double-stranded DNA (ds-DNA), histone (HIS), nuclear ribonucleoprotein (RNP), Sjogren’s syndrome A (SSA/Ro), Sjogren’s syndrome B (SSB/La) and Smith antigen, Jo-1, scleroderma-associated antigen (Scl-70) and centromere (CEN), zona pellucid (ZP), adrenocortical antibodies (ACA),Rheumatoid factor (RF), glomerular basement membrane (GBM), proliferating cell nuclear antigen (PCNA), myeloperoxidase (MPO), proteinase 3 (PR3), thyroid microsomal antibody and antinuclear antibody (ANA)were analyzed. RESULTS: Among the 96 women with POI and 100 age-matched health controls, women with POI had significantly elevated circulation levels of Jo-1 and PR3 (p = 0.010 and p = 0.001) whereas circulation levels of ANAs, dsDNA, histone, RNP, Sm, Scl-70, SSA, SSB, CEN, ZP, ACA, RF, GBM, PCNA, MPO and TM antibodies were similar between the two groups. CONCLUSIONS: This study shows that the autoimmune antibodies JO-1 and PR3 were significantly higher in POI women group which suggested that these antibodies may have played special role in POI, but the evaluation of the exact pathways of them remains to be determined.
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spelling pubmed-40161232014-05-10 Serologic autoimmunologic parameters in women with primary ovarian insufficiency Zhen, Xiumei Qiao, Jie Li, Rong Wang, Lina Liu, Ping BMC Immunol Research Article BACKGROUND: Primary ovarian insufficiency (POI) is heterogeneous disease defined by amenorrhea or premature depletion of ovarian follicles before the age of 40 years. The etiology of POI is still unclear. The purpose of this study is to evaluate whether women with POI have an elevated serum levels of autoimmunologic parameters. METHODS: The serum from peripheral blood samples which come from 96 POI patients and 100 age-matched health women were analyzed for a series of autoimmune antibodies using protein microarray. The antibodies to double-stranded DNA (ds-DNA), histone (HIS), nuclear ribonucleoprotein (RNP), Sjogren’s syndrome A (SSA/Ro), Sjogren’s syndrome B (SSB/La) and Smith antigen, Jo-1, scleroderma-associated antigen (Scl-70) and centromere (CEN), zona pellucid (ZP), adrenocortical antibodies (ACA),Rheumatoid factor (RF), glomerular basement membrane (GBM), proliferating cell nuclear antigen (PCNA), myeloperoxidase (MPO), proteinase 3 (PR3), thyroid microsomal antibody and antinuclear antibody (ANA)were analyzed. RESULTS: Among the 96 women with POI and 100 age-matched health controls, women with POI had significantly elevated circulation levels of Jo-1 and PR3 (p = 0.010 and p = 0.001) whereas circulation levels of ANAs, dsDNA, histone, RNP, Sm, Scl-70, SSA, SSB, CEN, ZP, ACA, RF, GBM, PCNA, MPO and TM antibodies were similar between the two groups. CONCLUSIONS: This study shows that the autoimmune antibodies JO-1 and PR3 were significantly higher in POI women group which suggested that these antibodies may have played special role in POI, but the evaluation of the exact pathways of them remains to be determined. BioMed Central 2014-03-10 /pmc/articles/PMC4016123/ /pubmed/24606591 http://dx.doi.org/10.1186/1471-2172-15-11 Text en Copyright © 2014 Zhen et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research Article
Zhen, Xiumei
Qiao, Jie
Li, Rong
Wang, Lina
Liu, Ping
Serologic autoimmunologic parameters in women with primary ovarian insufficiency
title Serologic autoimmunologic parameters in women with primary ovarian insufficiency
title_full Serologic autoimmunologic parameters in women with primary ovarian insufficiency
title_fullStr Serologic autoimmunologic parameters in women with primary ovarian insufficiency
title_full_unstemmed Serologic autoimmunologic parameters in women with primary ovarian insufficiency
title_short Serologic autoimmunologic parameters in women with primary ovarian insufficiency
title_sort serologic autoimmunologic parameters in women with primary ovarian insufficiency
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016123/
https://www.ncbi.nlm.nih.gov/pubmed/24606591
http://dx.doi.org/10.1186/1471-2172-15-11
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