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First Functional and Mutational Analysis of Group 3 N-Acetylneuraminate Lyases from Lactobacillus antri and Lactobacillus sakei 23K

N-acetyl neuraminate lyases (NALs) catalyze the reversible aldol cleavage of N-acetyl neuraminic acid (Neu5Ac) to pyruvate and N-acetyl-D-mannosamine (ManNAc). Previous phylogenetic studies divided NALs into four different groups. Groups 1 and 2 have been well characterized at both kinetic and molec...

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Detalles Bibliográficos
Autores principales: García-García, María Inmaculada, Gil-Ortiz, Fernando, García-Carmona, Francisco, Sánchez-Ferrer, Álvaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016182/
https://www.ncbi.nlm.nih.gov/pubmed/24817128
http://dx.doi.org/10.1371/journal.pone.0096976

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