Serological Cross-Reactivity between Merkel Cell Polyomavirus and Two Closely Related Chimpanzee Polyomaviruses

Phylogenetic analyses based on the major capsid protein sequence indicate that Merkel cell polyomavirus (MCPyV) and chimpanzee polyomaviruses (PtvPyV1, PtvPyV2), and similarly Trichodysplasia spinulosa-associated polyomavirus (TSPyV) and the orangutan polyomavirus (OraPyV1) are closely related. The...

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Autores principales: Nicol, Jérôme T. J., Liais, Etienne, Potier, Romain, Mazzoni, Elisa, Tognon, Mauro, Coursaget, Pierre, Touzé, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016208/
https://www.ncbi.nlm.nih.gov/pubmed/24816721
http://dx.doi.org/10.1371/journal.pone.0097030
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author Nicol, Jérôme T. J.
Liais, Etienne
Potier, Romain
Mazzoni, Elisa
Tognon, Mauro
Coursaget, Pierre
Touzé, Antoine
author_facet Nicol, Jérôme T. J.
Liais, Etienne
Potier, Romain
Mazzoni, Elisa
Tognon, Mauro
Coursaget, Pierre
Touzé, Antoine
author_sort Nicol, Jérôme T. J.
collection PubMed
description Phylogenetic analyses based on the major capsid protein sequence indicate that Merkel cell polyomavirus (MCPyV) and chimpanzee polyomaviruses (PtvPyV1, PtvPyV2), and similarly Trichodysplasia spinulosa-associated polyomavirus (TSPyV) and the orangutan polyomavirus (OraPyV1) are closely related. The existence of cross-reactivity between these polyomaviruses was therefore investigated. The findings indicated serological identity between the two chimpanzee polyomaviruses investigated and a high level of cross-reactivity with Merkel cell polyomavirus. In contrast, cross-reactivity was not observed between TSPyV and OraPyV1. Furthermore, specific antibodies to chimpanzee polyomaviruses were detected in chimpanzee sera by pre-incubation of sera with the different antigens, but not in human sera.
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spelling pubmed-40162082014-05-14 Serological Cross-Reactivity between Merkel Cell Polyomavirus and Two Closely Related Chimpanzee Polyomaviruses Nicol, Jérôme T. J. Liais, Etienne Potier, Romain Mazzoni, Elisa Tognon, Mauro Coursaget, Pierre Touzé, Antoine PLoS One Research Article Phylogenetic analyses based on the major capsid protein sequence indicate that Merkel cell polyomavirus (MCPyV) and chimpanzee polyomaviruses (PtvPyV1, PtvPyV2), and similarly Trichodysplasia spinulosa-associated polyomavirus (TSPyV) and the orangutan polyomavirus (OraPyV1) are closely related. The existence of cross-reactivity between these polyomaviruses was therefore investigated. The findings indicated serological identity between the two chimpanzee polyomaviruses investigated and a high level of cross-reactivity with Merkel cell polyomavirus. In contrast, cross-reactivity was not observed between TSPyV and OraPyV1. Furthermore, specific antibodies to chimpanzee polyomaviruses were detected in chimpanzee sera by pre-incubation of sera with the different antigens, but not in human sera. Public Library of Science 2014-05-09 /pmc/articles/PMC4016208/ /pubmed/24816721 http://dx.doi.org/10.1371/journal.pone.0097030 Text en © 2014 Nicol et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Nicol, Jérôme T. J.
Liais, Etienne
Potier, Romain
Mazzoni, Elisa
Tognon, Mauro
Coursaget, Pierre
Touzé, Antoine
Serological Cross-Reactivity between Merkel Cell Polyomavirus and Two Closely Related Chimpanzee Polyomaviruses
title Serological Cross-Reactivity between Merkel Cell Polyomavirus and Two Closely Related Chimpanzee Polyomaviruses
title_full Serological Cross-Reactivity between Merkel Cell Polyomavirus and Two Closely Related Chimpanzee Polyomaviruses
title_fullStr Serological Cross-Reactivity between Merkel Cell Polyomavirus and Two Closely Related Chimpanzee Polyomaviruses
title_full_unstemmed Serological Cross-Reactivity between Merkel Cell Polyomavirus and Two Closely Related Chimpanzee Polyomaviruses
title_short Serological Cross-Reactivity between Merkel Cell Polyomavirus and Two Closely Related Chimpanzee Polyomaviruses
title_sort serological cross-reactivity between merkel cell polyomavirus and two closely related chimpanzee polyomaviruses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016208/
https://www.ncbi.nlm.nih.gov/pubmed/24816721
http://dx.doi.org/10.1371/journal.pone.0097030
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