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An objective function exploiting suboptimal solutions in metabolic networks

BACKGROUND: Flux Balance Analysis is a theoretically elegant, computationally efficient, genome-scale approach to predicting biochemical reaction fluxes. Yet FBA models exhibit persistent mathematical degeneracy that generally limits their predictive power. RESULTS: We propose a novel objective func...

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Detalles Bibliográficos
Autores principales: Wintermute, Edwin H, Lieberman, Tami D, Silver, Pamela A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016239/
https://www.ncbi.nlm.nih.gov/pubmed/24088221
http://dx.doi.org/10.1186/1752-0509-7-98