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Socio-occupational class, region of birth and maternal age: influence on time to detection of cryptorchidism (undescended testes): a Danish nationwide register study
BACKGROUND: Cryptorchidism (undescended testes) is associated with poor male fertility, but can be alleviated and fertility preserved to some degree by early detection and treatment. Here we assess the influence of socio-occupational class, geographical region, maternal age and birth cohort on time...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016268/ https://www.ncbi.nlm.nih.gov/pubmed/24581337 http://dx.doi.org/10.1186/1471-2490-14-23 |
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author | Hougaard, Karin Sørig Larsen, Ann Dyreborg Hannerz, Harald Andersen, Anne-Marie Nybo Jørgensen, Kristian Tore Toft, Gunnar Vase Bonde, Jens Peter Jensen, Morten Søndergaard |
author_facet | Hougaard, Karin Sørig Larsen, Ann Dyreborg Hannerz, Harald Andersen, Anne-Marie Nybo Jørgensen, Kristian Tore Toft, Gunnar Vase Bonde, Jens Peter Jensen, Morten Søndergaard |
author_sort | Hougaard, Karin Sørig |
collection | PubMed |
description | BACKGROUND: Cryptorchidism (undescended testes) is associated with poor male fertility, but can be alleviated and fertility preserved to some degree by early detection and treatment. Here we assess the influence of socio-occupational class, geographical region, maternal age and birth cohort on time to detection and correction of cryptorchidism. METHODS: All boys born in Denmark, 1981 to 1987 or 1988 to 1994, with a diagnosis of cryptorchidism were identified in nationwide registers. The boys were followed for a diagnosis until their 16th birthday. The age at first diagnosis was noted and used as proxy for time to detection of cryptorchidism. Parental employment in the calendar year preceding birth was grouped into one of five socio-occupational classes. Geographical region was defined by place of birth in one of 15 Danish counties. Detection rate ratios of cryptorchidism were analyzed as a function of parental socio-occupational group, county, maternal age and birth cohort by use of Poisson regression. RESULTS: Some 6,059 boys in the early and 5,947 boys in the late cohort received a diagnosis of cryptorchidism. Time to detection was independent of parental socio-occupational group and maternal age but differed slightly between geographical regions. A similar pattern was obtained for surgical correction after a diagnosis. Age at diagnosis decreased by 2.7 years from the early to the late cohort. CONCLUSIONS: These results indicate that childhood socio-occupational inequality in detection and correction of cryptorchidism would play a negligible role in male infertility in a life course perspective. Geographical region may have exerted some influence, especially for the oldest cohort. |
format | Online Article Text |
id | pubmed-4016268 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40162682014-05-11 Socio-occupational class, region of birth and maternal age: influence on time to detection of cryptorchidism (undescended testes): a Danish nationwide register study Hougaard, Karin Sørig Larsen, Ann Dyreborg Hannerz, Harald Andersen, Anne-Marie Nybo Jørgensen, Kristian Tore Toft, Gunnar Vase Bonde, Jens Peter Jensen, Morten Søndergaard BMC Urol Research Article BACKGROUND: Cryptorchidism (undescended testes) is associated with poor male fertility, but can be alleviated and fertility preserved to some degree by early detection and treatment. Here we assess the influence of socio-occupational class, geographical region, maternal age and birth cohort on time to detection and correction of cryptorchidism. METHODS: All boys born in Denmark, 1981 to 1987 or 1988 to 1994, with a diagnosis of cryptorchidism were identified in nationwide registers. The boys were followed for a diagnosis until their 16th birthday. The age at first diagnosis was noted and used as proxy for time to detection of cryptorchidism. Parental employment in the calendar year preceding birth was grouped into one of five socio-occupational classes. Geographical region was defined by place of birth in one of 15 Danish counties. Detection rate ratios of cryptorchidism were analyzed as a function of parental socio-occupational group, county, maternal age and birth cohort by use of Poisson regression. RESULTS: Some 6,059 boys in the early and 5,947 boys in the late cohort received a diagnosis of cryptorchidism. Time to detection was independent of parental socio-occupational group and maternal age but differed slightly between geographical regions. A similar pattern was obtained for surgical correction after a diagnosis. Age at diagnosis decreased by 2.7 years from the early to the late cohort. CONCLUSIONS: These results indicate that childhood socio-occupational inequality in detection and correction of cryptorchidism would play a negligible role in male infertility in a life course perspective. Geographical region may have exerted some influence, especially for the oldest cohort. BioMed Central 2014-02-28 /pmc/articles/PMC4016268/ /pubmed/24581337 http://dx.doi.org/10.1186/1471-2490-14-23 Text en Copyright © 2014 Hougaard et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
spellingShingle | Research Article Hougaard, Karin Sørig Larsen, Ann Dyreborg Hannerz, Harald Andersen, Anne-Marie Nybo Jørgensen, Kristian Tore Toft, Gunnar Vase Bonde, Jens Peter Jensen, Morten Søndergaard Socio-occupational class, region of birth and maternal age: influence on time to detection of cryptorchidism (undescended testes): a Danish nationwide register study |
title | Socio-occupational class, region of birth and maternal age: influence on time to detection of cryptorchidism (undescended testes): a Danish nationwide register study |
title_full | Socio-occupational class, region of birth and maternal age: influence on time to detection of cryptorchidism (undescended testes): a Danish nationwide register study |
title_fullStr | Socio-occupational class, region of birth and maternal age: influence on time to detection of cryptorchidism (undescended testes): a Danish nationwide register study |
title_full_unstemmed | Socio-occupational class, region of birth and maternal age: influence on time to detection of cryptorchidism (undescended testes): a Danish nationwide register study |
title_short | Socio-occupational class, region of birth and maternal age: influence on time to detection of cryptorchidism (undescended testes): a Danish nationwide register study |
title_sort | socio-occupational class, region of birth and maternal age: influence on time to detection of cryptorchidism (undescended testes): a danish nationwide register study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016268/ https://www.ncbi.nlm.nih.gov/pubmed/24581337 http://dx.doi.org/10.1186/1471-2490-14-23 |
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