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Virus-Mediated shRNA Knockdown of Prodynorphin in the Rat Nucleus Accumbens Attenuates Depression-Like Behavior and Cocaine Locomotor Sensitization

Dynorphins, endogenous opioid peptides that arise from the precursor protein prodynorphin (Pdyn), are hypothesized to be involved in the regulation of mood states and the neuroplasticity associated with addiction. The current study tested the hypothesis that dynorphin in the nucleus accumbens (NAcc)...

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Detalles Bibliográficos
Autores principales:	Cohen, Ami, Whitfield, Timothy W., Kreifeldt, Max, Koebel, Pascale, Kieffer, Brigitte L., Contet, Candice, George, Olivier, Koob, George F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016270/ https://www.ncbi.nlm.nih.gov/pubmed/24816773 http://dx.doi.org/10.1371/journal.pone.0097216

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