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A simple strategy to decrease fatal carotid blowout syndrome after stereotactic body reirradiaton for recurrent head and neck cancers

BACKGROUND: This study aimed to compare the therapeutic outcomes and fatal carotid blow out syndrome (CBOS) incidence rates between two different stereotactic body radiotherapy (SBRT) protocols. METHODS: The study included 75 patients with inoperable locally recurrent head and neck cancer treated wi...

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Autores principales: Yazici, Gozde, Sanlı, Tolga Yusuf, Cengiz, Mustafa, Yuce, Deniz, Gultekin, Melis, Hurmuz, Pervin, Yıldız, Ferah, Zorlu, Faruk, Akyol, Fadil, Gurkaynak, Murat, Ozyigit, Gokhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016484/
https://www.ncbi.nlm.nih.gov/pubmed/24139288
http://dx.doi.org/10.1186/1748-717X-8-242
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author Yazici, Gozde
Sanlı, Tolga Yusuf
Cengiz, Mustafa
Yuce, Deniz
Gultekin, Melis
Hurmuz, Pervin
Yıldız, Ferah
Zorlu, Faruk
Akyol, Fadil
Gurkaynak, Murat
Ozyigit, Gokhan
author_facet Yazici, Gozde
Sanlı, Tolga Yusuf
Cengiz, Mustafa
Yuce, Deniz
Gultekin, Melis
Hurmuz, Pervin
Yıldız, Ferah
Zorlu, Faruk
Akyol, Fadil
Gurkaynak, Murat
Ozyigit, Gokhan
author_sort Yazici, Gozde
collection PubMed
description BACKGROUND: This study aimed to compare the therapeutic outcomes and fatal carotid blow out syndrome (CBOS) incidence rates between two different stereotactic body radiotherapy (SBRT) protocols. METHODS: The study included 75 patients with inoperable locally recurrent head and neck cancer treated with SBRT in our department between June 2007 and March 2011. The first 43 patients were treated sequentially (group I). Then our SBRT protocol was changed due to the high rate of CBOS, and the following 32 patients were treated every other day in a prospective institutional protocol (group II). RESULTS: Median overall survival in group I and group II was 11 months and 23 months, respectively (P = 0.006). We observed 11 cases of CBOS. Only 1 of 7 patients (14%) with CBOS survived in group I, whereas 2 of 4 patients (50%) in group II remain alive. CBOS free median overall survivals were 9 months, and 23 months in group I and group II respectively (P = 0.002). The median radiation dose received by the carotid artery in patients with CBOS was 36.5 Gy (range: 34–42.8 Gy), versus 34.7 Gy (range: 0–44 Gy) in the patients that didn’t have CBOS (P = 0.15). CBOS did not occur in any of the patients with a maximum carotid artery radiation dose <34 Gy. CONCLUSIONS: Every other day SBRT protocol for re-irradiation of recurrent head and neck cancer is promising in terms of decreasing the incidence of fatal CBOS.
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spelling pubmed-40164842014-05-11 A simple strategy to decrease fatal carotid blowout syndrome after stereotactic body reirradiaton for recurrent head and neck cancers Yazici, Gozde Sanlı, Tolga Yusuf Cengiz, Mustafa Yuce, Deniz Gultekin, Melis Hurmuz, Pervin Yıldız, Ferah Zorlu, Faruk Akyol, Fadil Gurkaynak, Murat Ozyigit, Gokhan Radiat Oncol Research BACKGROUND: This study aimed to compare the therapeutic outcomes and fatal carotid blow out syndrome (CBOS) incidence rates between two different stereotactic body radiotherapy (SBRT) protocols. METHODS: The study included 75 patients with inoperable locally recurrent head and neck cancer treated with SBRT in our department between June 2007 and March 2011. The first 43 patients were treated sequentially (group I). Then our SBRT protocol was changed due to the high rate of CBOS, and the following 32 patients were treated every other day in a prospective institutional protocol (group II). RESULTS: Median overall survival in group I and group II was 11 months and 23 months, respectively (P = 0.006). We observed 11 cases of CBOS. Only 1 of 7 patients (14%) with CBOS survived in group I, whereas 2 of 4 patients (50%) in group II remain alive. CBOS free median overall survivals were 9 months, and 23 months in group I and group II respectively (P = 0.002). The median radiation dose received by the carotid artery in patients with CBOS was 36.5 Gy (range: 34–42.8 Gy), versus 34.7 Gy (range: 0–44 Gy) in the patients that didn’t have CBOS (P = 0.15). CBOS did not occur in any of the patients with a maximum carotid artery radiation dose <34 Gy. CONCLUSIONS: Every other day SBRT protocol for re-irradiation of recurrent head and neck cancer is promising in terms of decreasing the incidence of fatal CBOS. BioMed Central 2013-10-18 /pmc/articles/PMC4016484/ /pubmed/24139288 http://dx.doi.org/10.1186/1748-717X-8-242 Text en Copyright © 2013 Yazici et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Yazici, Gozde
Sanlı, Tolga Yusuf
Cengiz, Mustafa
Yuce, Deniz
Gultekin, Melis
Hurmuz, Pervin
Yıldız, Ferah
Zorlu, Faruk
Akyol, Fadil
Gurkaynak, Murat
Ozyigit, Gokhan
A simple strategy to decrease fatal carotid blowout syndrome after stereotactic body reirradiaton for recurrent head and neck cancers
title A simple strategy to decrease fatal carotid blowout syndrome after stereotactic body reirradiaton for recurrent head and neck cancers
title_full A simple strategy to decrease fatal carotid blowout syndrome after stereotactic body reirradiaton for recurrent head and neck cancers
title_fullStr A simple strategy to decrease fatal carotid blowout syndrome after stereotactic body reirradiaton for recurrent head and neck cancers
title_full_unstemmed A simple strategy to decrease fatal carotid blowout syndrome after stereotactic body reirradiaton for recurrent head and neck cancers
title_short A simple strategy to decrease fatal carotid blowout syndrome after stereotactic body reirradiaton for recurrent head and neck cancers
title_sort simple strategy to decrease fatal carotid blowout syndrome after stereotactic body reirradiaton for recurrent head and neck cancers
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016484/
https://www.ncbi.nlm.nih.gov/pubmed/24139288
http://dx.doi.org/10.1186/1748-717X-8-242
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