Is there a role for high dose chemotherapy and blood stem cell rescue in childhood hepatoblastoma presenting with lung metastases? A case report and literature review

We report the use of high dose chemotherapy with peripheral blood stem cell rescue as a consolidation treatment for a 3-year-old child affected by metastatic hepatoblastoma, who achieved complete lung response only after conventional treatment. The patient is presently alive 27 months after high dos...

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Autores principales: Provenzi, Massimo, Saettini, Francesco, Conter, Valentino, Giraldi, Eugenia, Foglia, Carlo, Cavalleri, Laura, Colledan, Michele, D’Antiga, Lorenzo, Perilongo, Giorgio, Da Dalt, Liviana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016556/
https://www.ncbi.nlm.nih.gov/pubmed/24148885
http://dx.doi.org/10.1186/1824-7288-39-65
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author Provenzi, Massimo
Saettini, Francesco
Conter, Valentino
Giraldi, Eugenia
Foglia, Carlo
Cavalleri, Laura
Colledan, Michele
D’Antiga, Lorenzo
Perilongo, Giorgio
Da Dalt, Liviana
author_facet Provenzi, Massimo
Saettini, Francesco
Conter, Valentino
Giraldi, Eugenia
Foglia, Carlo
Cavalleri, Laura
Colledan, Michele
D’Antiga, Lorenzo
Perilongo, Giorgio
Da Dalt, Liviana
author_sort Provenzi, Massimo
collection PubMed
description We report the use of high dose chemotherapy with peripheral blood stem cell rescue as a consolidation treatment for a 3-year-old child affected by metastatic hepatoblastoma, who achieved complete lung response only after conventional treatment. The patient is presently alive 27 months after high dose chemotherapy with blood stem cell rescue with no evidence of disease. The role of high dose chemotherapy with blood stem cell rescue to consolidate the complete clearing of lung disease in metastatic hepatoblastoma remains controversial; the data available in the literature and our experience seems to suggest to keep this treatment option open to further consideration in the clinical setting of high-risk patients.
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spelling pubmed-40165562014-05-11 Is there a role for high dose chemotherapy and blood stem cell rescue in childhood hepatoblastoma presenting with lung metastases? A case report and literature review Provenzi, Massimo Saettini, Francesco Conter, Valentino Giraldi, Eugenia Foglia, Carlo Cavalleri, Laura Colledan, Michele D’Antiga, Lorenzo Perilongo, Giorgio Da Dalt, Liviana Ital J Pediatr Case Report We report the use of high dose chemotherapy with peripheral blood stem cell rescue as a consolidation treatment for a 3-year-old child affected by metastatic hepatoblastoma, who achieved complete lung response only after conventional treatment. The patient is presently alive 27 months after high dose chemotherapy with blood stem cell rescue with no evidence of disease. The role of high dose chemotherapy with blood stem cell rescue to consolidate the complete clearing of lung disease in metastatic hepatoblastoma remains controversial; the data available in the literature and our experience seems to suggest to keep this treatment option open to further consideration in the clinical setting of high-risk patients. BioMed Central 2013-10-22 /pmc/articles/PMC4016556/ /pubmed/24148885 http://dx.doi.org/10.1186/1824-7288-39-65 Text en Copyright © 2013 Provenzi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Provenzi, Massimo
Saettini, Francesco
Conter, Valentino
Giraldi, Eugenia
Foglia, Carlo
Cavalleri, Laura
Colledan, Michele
D’Antiga, Lorenzo
Perilongo, Giorgio
Da Dalt, Liviana
Is there a role for high dose chemotherapy and blood stem cell rescue in childhood hepatoblastoma presenting with lung metastases? A case report and literature review
title Is there a role for high dose chemotherapy and blood stem cell rescue in childhood hepatoblastoma presenting with lung metastases? A case report and literature review
title_full Is there a role for high dose chemotherapy and blood stem cell rescue in childhood hepatoblastoma presenting with lung metastases? A case report and literature review
title_fullStr Is there a role for high dose chemotherapy and blood stem cell rescue in childhood hepatoblastoma presenting with lung metastases? A case report and literature review
title_full_unstemmed Is there a role for high dose chemotherapy and blood stem cell rescue in childhood hepatoblastoma presenting with lung metastases? A case report and literature review
title_short Is there a role for high dose chemotherapy and blood stem cell rescue in childhood hepatoblastoma presenting with lung metastases? A case report and literature review
title_sort is there a role for high dose chemotherapy and blood stem cell rescue in childhood hepatoblastoma presenting with lung metastases? a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016556/
https://www.ncbi.nlm.nih.gov/pubmed/24148885
http://dx.doi.org/10.1186/1824-7288-39-65
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