A new piece in the puzzle of the novel avian-origin influenza A (H7N9) virus

REVIEWERS: This article was reviewed by Prof Xiufan Liu (nominated by Dr Purificacion Lopez-Garcia) and Prof Sandor Pongor. Using phylogenetic analysis on newly available sequences, we characterize A/chicken/Jiangsu/RD5/2013(H10N9) as currently closest precursor strain for the NA segment in the nove...

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Autores principales: Lee, Raphael Tze Chuen, Gunalan, Vithiagaran, Van, Thanh Dac, Le, Ly Thi, Eisenhaber, Frank, Maurer-Stroh, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Discovery Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016609/
https://www.ncbi.nlm.nih.gov/pubmed/24160334
http://dx.doi.org/10.1186/1745-6150-8-26
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author Lee, Raphael Tze Chuen
Gunalan, Vithiagaran
Van, Thanh Dac
Le, Ly Thi
Eisenhaber, Frank
Maurer-Stroh, Sebastian
author_facet Lee, Raphael Tze Chuen
Gunalan, Vithiagaran
Van, Thanh Dac
Le, Ly Thi
Eisenhaber, Frank
Maurer-Stroh, Sebastian
author_sort Lee, Raphael Tze Chuen
collection PubMed
description REVIEWERS: This article was reviewed by Prof Xiufan Liu (nominated by Dr Purificacion Lopez-Garcia) and Prof Sandor Pongor. Using phylogenetic analysis on newly available sequences, we characterize A/chicken/Jiangsu/RD5/2013(H10N9) as currently closest precursor strain for the NA segment in the novel avian-origin H7N9 virus responsible for an outbreak in China. We also show that the internal segments of this precursor strain are closely related to those of the presumed precursor for the HA segment, A/duck/Zhejiang/12/2011(H7N3), which indicates that the sources of both HA and NA donors for the reassortant virus are of regional and not migratory-bird origin and highlights the role of chicken already in the early reassortment events.
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spelling pubmed-40166092014-05-11 A new piece in the puzzle of the novel avian-origin influenza A (H7N9) virus Lee, Raphael Tze Chuen Gunalan, Vithiagaran Van, Thanh Dac Le, Ly Thi Eisenhaber, Frank Maurer-Stroh, Sebastian Biol Direct Discovery Notes REVIEWERS: This article was reviewed by Prof Xiufan Liu (nominated by Dr Purificacion Lopez-Garcia) and Prof Sandor Pongor. Using phylogenetic analysis on newly available sequences, we characterize A/chicken/Jiangsu/RD5/2013(H10N9) as currently closest precursor strain for the NA segment in the novel avian-origin H7N9 virus responsible for an outbreak in China. We also show that the internal segments of this precursor strain are closely related to those of the presumed precursor for the HA segment, A/duck/Zhejiang/12/2011(H7N3), which indicates that the sources of both HA and NA donors for the reassortant virus are of regional and not migratory-bird origin and highlights the role of chicken already in the early reassortment events. BioMed Central 2013-10-26 /pmc/articles/PMC4016609/ /pubmed/24160334 http://dx.doi.org/10.1186/1745-6150-8-26 Text en Copyright © 2013 Lee et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Discovery Notes
Lee, Raphael Tze Chuen
Gunalan, Vithiagaran
Van, Thanh Dac
Le, Ly Thi
Eisenhaber, Frank
Maurer-Stroh, Sebastian
A new piece in the puzzle of the novel avian-origin influenza A (H7N9) virus
title A new piece in the puzzle of the novel avian-origin influenza A (H7N9) virus
title_full A new piece in the puzzle of the novel avian-origin influenza A (H7N9) virus
title_fullStr A new piece in the puzzle of the novel avian-origin influenza A (H7N9) virus
title_full_unstemmed A new piece in the puzzle of the novel avian-origin influenza A (H7N9) virus
title_short A new piece in the puzzle of the novel avian-origin influenza A (H7N9) virus
title_sort new piece in the puzzle of the novel avian-origin influenza a (h7n9) virus
topic Discovery Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016609/
https://www.ncbi.nlm.nih.gov/pubmed/24160334
http://dx.doi.org/10.1186/1745-6150-8-26
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