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High burden of malaria following scale-up of control interventions in Nchelenge District, Luapula Province, Zambia

BACKGROUND: Malaria control interventions have been scaled-up in Zambia in conjunction with a malaria surveillance system. Although substantial progress has been achieved in reducing morbidity and mortality, national and local information demonstrated marked heterogeneity in the impact of malaria co...

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Autores principales: Mukonka, Victor M, Chanda, Emmanuel, Haque, Ubydul, Kamuliwo, Mulakwa, Mushinge, Gabriel, Chileshe, Jackson, Chibwe, Kennedy A, Norris, Douglas E, Mulenga, Modest, Chaponda, Mike, Muleba, Mbanga, Glass, Gregory E, Moss, William J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016669/
https://www.ncbi.nlm.nih.gov/pubmed/24755108
http://dx.doi.org/10.1186/1475-2875-13-153
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author Mukonka, Victor M
Chanda, Emmanuel
Haque, Ubydul
Kamuliwo, Mulakwa
Mushinge, Gabriel
Chileshe, Jackson
Chibwe, Kennedy A
Norris, Douglas E
Mulenga, Modest
Chaponda, Mike
Muleba, Mbanga
Glass, Gregory E
Moss, William J
author_facet Mukonka, Victor M
Chanda, Emmanuel
Haque, Ubydul
Kamuliwo, Mulakwa
Mushinge, Gabriel
Chileshe, Jackson
Chibwe, Kennedy A
Norris, Douglas E
Mulenga, Modest
Chaponda, Mike
Muleba, Mbanga
Glass, Gregory E
Moss, William J
author_sort Mukonka, Victor M
collection PubMed
description BACKGROUND: Malaria control interventions have been scaled-up in Zambia in conjunction with a malaria surveillance system. Although substantial progress has been achieved in reducing morbidity and mortality, national and local information demonstrated marked heterogeneity in the impact of malaria control across the country. This study reports the high burden of malaria in Nchelenge District, Luapula Province, Zambia from 2006 to 2012 after seven years of control measures. METHODS: Yearly aggregated information on cases of malaria, malaria deaths, use of malaria diagnostics, and malaria control interventions from 2006 to 2012 were obtained from the Nchelenge District Health Office. Trends in the number of malaria cases, methods of diagnosis, malaria positivity rate among pregnant women, and intervention coverage were analysed using descriptive statistics. RESULTS: Malaria prevalence remained high, increasing from 38% in 2006 to 53% in 2012. Increasing numbers of cases of severe malaria were reported until 2010. Intense seasonal malaria transmission was observed with seasonal declines in the number of cases between April and August, although malaria transmission continued throughout the year. Clinical diagnosis without accompanying confirmation declined from 95% in 2006 to 35% in 2012. Intervention coverage with long-lasting insecticide-treated nets and indoor residual spraying increased from 2006 to 2012. CONCLUSIONS: Despite high coverage with vector control interventions, the burden of malaria in Nchelenge District, Zambia remained high. The high parasite prevalence could accurately reflect the true burden, perhaps in part as a consequence of population movement, or improved access to care and case reporting. Quality information at fine spatial scales will be critical for targeting effective interventions and measurement of progress.
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spelling pubmed-40166692014-05-11 High burden of malaria following scale-up of control interventions in Nchelenge District, Luapula Province, Zambia Mukonka, Victor M Chanda, Emmanuel Haque, Ubydul Kamuliwo, Mulakwa Mushinge, Gabriel Chileshe, Jackson Chibwe, Kennedy A Norris, Douglas E Mulenga, Modest Chaponda, Mike Muleba, Mbanga Glass, Gregory E Moss, William J Malar J Research BACKGROUND: Malaria control interventions have been scaled-up in Zambia in conjunction with a malaria surveillance system. Although substantial progress has been achieved in reducing morbidity and mortality, national and local information demonstrated marked heterogeneity in the impact of malaria control across the country. This study reports the high burden of malaria in Nchelenge District, Luapula Province, Zambia from 2006 to 2012 after seven years of control measures. METHODS: Yearly aggregated information on cases of malaria, malaria deaths, use of malaria diagnostics, and malaria control interventions from 2006 to 2012 were obtained from the Nchelenge District Health Office. Trends in the number of malaria cases, methods of diagnosis, malaria positivity rate among pregnant women, and intervention coverage were analysed using descriptive statistics. RESULTS: Malaria prevalence remained high, increasing from 38% in 2006 to 53% in 2012. Increasing numbers of cases of severe malaria were reported until 2010. Intense seasonal malaria transmission was observed with seasonal declines in the number of cases between April and August, although malaria transmission continued throughout the year. Clinical diagnosis without accompanying confirmation declined from 95% in 2006 to 35% in 2012. Intervention coverage with long-lasting insecticide-treated nets and indoor residual spraying increased from 2006 to 2012. CONCLUSIONS: Despite high coverage with vector control interventions, the burden of malaria in Nchelenge District, Zambia remained high. The high parasite prevalence could accurately reflect the true burden, perhaps in part as a consequence of population movement, or improved access to care and case reporting. Quality information at fine spatial scales will be critical for targeting effective interventions and measurement of progress. BioMed Central 2014-04-23 /pmc/articles/PMC4016669/ /pubmed/24755108 http://dx.doi.org/10.1186/1475-2875-13-153 Text en Copyright © 2014 Mukonka et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Mukonka, Victor M
Chanda, Emmanuel
Haque, Ubydul
Kamuliwo, Mulakwa
Mushinge, Gabriel
Chileshe, Jackson
Chibwe, Kennedy A
Norris, Douglas E
Mulenga, Modest
Chaponda, Mike
Muleba, Mbanga
Glass, Gregory E
Moss, William J
High burden of malaria following scale-up of control interventions in Nchelenge District, Luapula Province, Zambia
title High burden of malaria following scale-up of control interventions in Nchelenge District, Luapula Province, Zambia
title_full High burden of malaria following scale-up of control interventions in Nchelenge District, Luapula Province, Zambia
title_fullStr High burden of malaria following scale-up of control interventions in Nchelenge District, Luapula Province, Zambia
title_full_unstemmed High burden of malaria following scale-up of control interventions in Nchelenge District, Luapula Province, Zambia
title_short High burden of malaria following scale-up of control interventions in Nchelenge District, Luapula Province, Zambia
title_sort high burden of malaria following scale-up of control interventions in nchelenge district, luapula province, zambia
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016669/
https://www.ncbi.nlm.nih.gov/pubmed/24755108
http://dx.doi.org/10.1186/1475-2875-13-153
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