Cargando…

Hyperglycemia, a Neglected Factor during Cancer Progression

Recent evidence from large cohort studies suggests that there exists a higher cancer incidence in people with type 2 diabetes (DM2). However, to date, the potential reasons for this association remain unclear. Hyperglycemia, the most important feature of diabetes, may be responsible for the excess g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Duan, Wanxing, Shen, Xin, Lei, Jianjun, Xu, Qinhong, Yu, Yongtian, Li, Rong, Wu, Erxi, Ma, Qingyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016871/ https://www.ncbi.nlm.nih.gov/pubmed/24864247 http://dx.doi.org/10.1155/2014/461917

Ejemplares similares

Hydrogen peroxide mediates hyperglycemia-induced invasive activity via ERK and p38 MAPK in human pancreatic cancer
por: Li, Wei, et al.
Publicado: (2015)

Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner
por: Lei, Jianjun, et al.
Publicado: (2013)

α-Mangostin Suppresses the Viability and Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells by Downregulating the PI3K/Akt Pathway
por: Xu, Qinhong, et al.
Publicado: (2014)

β(2)-Adrenogenic signaling regulates NNK-induced pancreatic cancer progression via upregulation of HIF-1α
por: Zhang, Dong, et al.
Publicado: (2015)

Chronic alcohol exposure exacerbates inflammation and triggers pancreatic acinar-to-ductal metaplasia through PI3K/Akt/IKK
por: HUANG, XIN, et al.
Publicado: (2015)

Chronic alcohol exposure exacerbates inflammation and triggers pancreatic acinar-to-ductal metaplasia through PI3K/Akt/IKK
por: Huang, Xin, et al.
Publicado: (2023)

Overexpression of Nodal induces a metastatic phenotype in pancreatic cancer cells via the Smad2/3 pathway
por: Duan, Wanxing, et al.
Publicado: (2015)

Pancreatic stellate cells contribute pancreatic cancer pain via activation of sHH signaling pathway
por: Han, Liang, et al.
Publicado: (2016)

Stromal-derived factor-1α/CXCL12-CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer
por: Xu, Qinhong, et al.
Publicado: (2014)

Resveratrol Ameliorates the Malignant Progression of Pancreatic Cancer by Inhibiting Hypoxia-induced Pancreatic Stellate Cell Activation
por: Xiao, Ying, et al.
Publicado: (2020)

miR-221/222 induces pancreatic cancer progression through the regulation of matrix metalloproteinases
por: Xu, Qinhong, et al.
Publicado: (2015)

Editorial: The Microenvironment in Pancreatic Cancer and Therapeutic Strategies Targeting Microenvironment
por: Duan, Wanxing, et al.
Publicado: (2022)

Inhibiting YAP expression suppresses pancreatic cancer progression by disrupting tumor-stromal interactions
por: Jiang, Zhengdong, et al.
Publicado: (2018)

PTTG regulates the metabolic switch of ovarian cancer cells via the c-myc pathway
por: Wang, Xiu, et al.
Publicado: (2015)

NAF-1 Inhibition by Resveratrol Suppresses Cancer Stem Cell-Like Properties and the Invasion of Pancreatic Cancer
por: Qin, Tao, et al.
Publicado: (2020)

Pancreatic carcinoma-specific immunotherapy using novel tumor specific cytotoxic T cells
por: Lei, Jianjun, et al.
Publicado: (2016)

Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis
por: Ma, Jiguang, et al.
Publicado: (2015)

The Relevance of Nrf2 Pathway and Autophagy in Pancreatic Cancer Cells upon Stimulation of Reactive Oxygen Species
por: Zhang, Lun, et al.
Publicado: (2016)

Lipoxin A(4) Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer
por: Zong, Liang, et al.
Publicado: (2016)

Hyperglycemia aggravates microenvironment hypoxia and promotes the metastatic ability of pancreatic cancer
por: Li, Wei, et al.
Publicado: (2018)

Relationship between Neural Alteration and Perineural Invasion in Pancreatic Cancer Patients with Hyperglycemia
por: Li, Junhui, et al.
Publicado: (2011)

Betulinic acid inhibits stemness and EMT of pancreatic cancer cells via activation of AMPK signaling
por: Sun, Liankang, et al.
Publicado: (2018)

Lipoxin A4 reverses mesenchymal phenotypes to attenuate invasion and metastasis via the inhibition of autocrine TGF-β1 signaling in pancreatic cancer
por: Zong, Liang, et al.
Publicado: (2017)

High Glucose Promotes Pancreatic Cancer Cell Proliferation via the Induction of EGF Expression and Transactivation of EGFR
por: Han, Liang, et al.
Publicado: (2011)

Curcumin Suppresses Hepatic Stellate Cell-Induced Hepatocarcinoma Angiogenesis and Invasion through Downregulating CTGF
por: Shao, Shan, et al.
Publicado: (2019)

Targeting the SLIT/ROBO pathway in tumor progression: molecular mechanisms and therapeutic perspectives
por: Jiang, Zhengdong, et al.
Publicado: (2019)

Disrupting the Balance between Tumor Epithelia and Stroma is a Possible Therapeutic Approach for Pancreatic Cancer
por: Wang, Zheng, et al.
Publicado: (2014)

Resveratrol enhances the chemotherapeutic response and reverses the stemness induced by gemcitabine in pancreatic cancer cells via targeting SREBP1
por: Zhou, Cancan, et al.
Publicado: (2018)

Hyperglycemia Promotes the Epithelial-Mesenchymal Transition of Pancreatic Cancer via Hydrogen Peroxide
por: Li, Wei, et al.
Publicado: (2016)

The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer
por: Qian, Weikun, et al.
Publicado: (2021)

Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer
por: Chen, Ke, et al.
Publicado: (2017)

Hyperglycemia as a Risk Factor for Cancer Progression
por: Ryu, Tae Young, et al.
Publicado: (2014)

Hypoxia‐driven paracrine osteopontin/integrin αvβ3 signaling promotes pancreatic cancer cell epithelial–mesenchymal transition and cancer stem cell‐like properties by modulating forkhead box protein M1
por: Cao, Junyu, et al.
Publicado: (2018)

Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions
por: Chen, Xin, et al.
Publicado: (2021)

Calcium-sensing receptor expression in insulin-negative, intrapancreatic insulinoma
por: Qian, Weikun, et al.
Publicado: (2022)

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone provokes progression from chronic pancreatitis to pancreatic intraepithelial neoplasia
por: Chen, Xin, et al.
Publicado: (2021)

Overexpression of Gremlin 1 by sonic hedgehog signaling promotes pancreatic cancer progression
por: Yu, Yongtian, et al.
Publicado: (2018)

YAP Inhibition by Resveratrol via Activation of AMPK Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine
por: Jiang, Zhengdong, et al.
Publicado: (2016)

Cav-1 Ablation in Pancreatic Stellate Cells Promotes Pancreatic Cancer Growth through Nrf2-Induced shh Signaling
por: Shao, Shan, et al.
Publicado: (2020)

Molecular Interactions of the Long Noncoding RNA NEAT1 in Cancer
por: Gu, Jingtao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9k30d1gabrqhvq6es26mpsop29