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Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis
Background. In multiple sclerosis (MS), symptom management and improved health-related quality of life (HrQOL) may be modified by smoking. Objective. To evaluate the extent to which smoking is associated with worsened health outcomes and HrQOL for postmenopausal women with MS. Methods. We identified...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016891/ https://www.ncbi.nlm.nih.gov/pubmed/24860668 http://dx.doi.org/10.1155/2014/686045 |
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author | Jawahar, Rachel Oh, Unsong Eaton, Charles Wright, Nicole Tindle, Hilary Lapane, Kate L. |
author_facet | Jawahar, Rachel Oh, Unsong Eaton, Charles Wright, Nicole Tindle, Hilary Lapane, Kate L. |
author_sort | Jawahar, Rachel |
collection | PubMed |
description | Background. In multiple sclerosis (MS), symptom management and improved health-related quality of life (HrQOL) may be modified by smoking. Objective. To evaluate the extent to which smoking is associated with worsened health outcomes and HrQOL for postmenopausal women with MS. Methods. We identified 251 Women's Health Initiative Observational Study participants with a self-reported MS diagnosis. Using a linear model, we estimated changes from baseline to 3 years for activities of daily living, total metabolic equivalent tasks (MET) hours per week, mental and physical component scales (MCS, PCS) of the SF-36, and menopausal symptoms adjusting for years since menopause and other confounders. Results. Nine percent were current and 50% past smokers. Age at smoking initiation was associated with significant changes in MCS during menopause. PCS scores were unchanged. While women who had ever smoked experienced an increase in physical activity during menopause, the physical activity levels of women who never smoked declined. Residual confounding may explain this finding. Smoking was not associated with change in menopausal symptoms during the 3-year follow-up. Conclusion. Smoking was not associated with health outcomes among post-menopausal women with MS. |
format | Online Article Text |
id | pubmed-4016891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40168912014-05-25 Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis Jawahar, Rachel Oh, Unsong Eaton, Charles Wright, Nicole Tindle, Hilary Lapane, Kate L. Mult Scler Int Research Article Background. In multiple sclerosis (MS), symptom management and improved health-related quality of life (HrQOL) may be modified by smoking. Objective. To evaluate the extent to which smoking is associated with worsened health outcomes and HrQOL for postmenopausal women with MS. Methods. We identified 251 Women's Health Initiative Observational Study participants with a self-reported MS diagnosis. Using a linear model, we estimated changes from baseline to 3 years for activities of daily living, total metabolic equivalent tasks (MET) hours per week, mental and physical component scales (MCS, PCS) of the SF-36, and menopausal symptoms adjusting for years since menopause and other confounders. Results. Nine percent were current and 50% past smokers. Age at smoking initiation was associated with significant changes in MCS during menopause. PCS scores were unchanged. While women who had ever smoked experienced an increase in physical activity during menopause, the physical activity levels of women who never smoked declined. Residual confounding may explain this finding. Smoking was not associated with change in menopausal symptoms during the 3-year follow-up. Conclusion. Smoking was not associated with health outcomes among post-menopausal women with MS. Hindawi Publishing Corporation 2014 2014-04-22 /pmc/articles/PMC4016891/ /pubmed/24860668 http://dx.doi.org/10.1155/2014/686045 Text en Copyright © 2014 Rachel Jawahar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Jawahar, Rachel Oh, Unsong Eaton, Charles Wright, Nicole Tindle, Hilary Lapane, Kate L. Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis |
title | Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis |
title_full | Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis |
title_fullStr | Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis |
title_full_unstemmed | Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis |
title_short | Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis |
title_sort | association between smoking and health outcomes in postmenopausal women living with multiple sclerosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016891/ https://www.ncbi.nlm.nih.gov/pubmed/24860668 http://dx.doi.org/10.1155/2014/686045 |
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