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Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis

Background. In multiple sclerosis (MS), symptom management and improved health-related quality of life (HrQOL) may be modified by smoking. Objective. To evaluate the extent to which smoking is associated with worsened health outcomes and HrQOL for postmenopausal women with MS. Methods. We identified...

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Autores principales: Jawahar, Rachel, Oh, Unsong, Eaton, Charles, Wright, Nicole, Tindle, Hilary, Lapane, Kate L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016891/
https://www.ncbi.nlm.nih.gov/pubmed/24860668
http://dx.doi.org/10.1155/2014/686045
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author Jawahar, Rachel
Oh, Unsong
Eaton, Charles
Wright, Nicole
Tindle, Hilary
Lapane, Kate L.
author_facet Jawahar, Rachel
Oh, Unsong
Eaton, Charles
Wright, Nicole
Tindle, Hilary
Lapane, Kate L.
author_sort Jawahar, Rachel
collection PubMed
description Background. In multiple sclerosis (MS), symptom management and improved health-related quality of life (HrQOL) may be modified by smoking. Objective. To evaluate the extent to which smoking is associated with worsened health outcomes and HrQOL for postmenopausal women with MS. Methods. We identified 251 Women's Health Initiative Observational Study participants with a self-reported MS diagnosis. Using a linear model, we estimated changes from baseline to 3 years for activities of daily living, total metabolic equivalent tasks (MET) hours per week, mental and physical component scales (MCS, PCS) of the SF-36, and menopausal symptoms adjusting for years since menopause and other confounders. Results. Nine percent were current and 50% past smokers. Age at smoking initiation was associated with significant changes in MCS during menopause. PCS scores were unchanged. While women who had ever smoked experienced an increase in physical activity during menopause, the physical activity levels of women who never smoked declined. Residual confounding may explain this finding. Smoking was not associated with change in menopausal symptoms during the 3-year follow-up. Conclusion. Smoking was not associated with health outcomes among post-menopausal women with MS.
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spelling pubmed-40168912014-05-25 Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis Jawahar, Rachel Oh, Unsong Eaton, Charles Wright, Nicole Tindle, Hilary Lapane, Kate L. Mult Scler Int Research Article Background. In multiple sclerosis (MS), symptom management and improved health-related quality of life (HrQOL) may be modified by smoking. Objective. To evaluate the extent to which smoking is associated with worsened health outcomes and HrQOL for postmenopausal women with MS. Methods. We identified 251 Women's Health Initiative Observational Study participants with a self-reported MS diagnosis. Using a linear model, we estimated changes from baseline to 3 years for activities of daily living, total metabolic equivalent tasks (MET) hours per week, mental and physical component scales (MCS, PCS) of the SF-36, and menopausal symptoms adjusting for years since menopause and other confounders. Results. Nine percent were current and 50% past smokers. Age at smoking initiation was associated with significant changes in MCS during menopause. PCS scores were unchanged. While women who had ever smoked experienced an increase in physical activity during menopause, the physical activity levels of women who never smoked declined. Residual confounding may explain this finding. Smoking was not associated with change in menopausal symptoms during the 3-year follow-up. Conclusion. Smoking was not associated with health outcomes among post-menopausal women with MS. Hindawi Publishing Corporation 2014 2014-04-22 /pmc/articles/PMC4016891/ /pubmed/24860668 http://dx.doi.org/10.1155/2014/686045 Text en Copyright © 2014 Rachel Jawahar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jawahar, Rachel
Oh, Unsong
Eaton, Charles
Wright, Nicole
Tindle, Hilary
Lapane, Kate L.
Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis
title Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis
title_full Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis
title_fullStr Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis
title_full_unstemmed Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis
title_short Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis
title_sort association between smoking and health outcomes in postmenopausal women living with multiple sclerosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016891/
https://www.ncbi.nlm.nih.gov/pubmed/24860668
http://dx.doi.org/10.1155/2014/686045
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