Cargando…

Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index

FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The...

Descripción completa

Detalles Bibliográficos
Autores principales: Pardo, María, Crujeiras, Ana B., Amil, María, Aguera, Zaida, Jiménez-Murcia, Susana, Baños, Rosa, Botella, Cristina, de la Torre, Rafael, Estivill, Xavier, Fagundo, Ana B., Fernández-Real, Jose M., Fernández-García, José C., Fruhbeck, Gema, Gómez-Ambrosi, Javier, Rodríguez, Roser, Tinahones, Francisco J., Fernández-Aranda, Fernando, Casanueva, Felipe F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016898/
https://www.ncbi.nlm.nih.gov/pubmed/24864142
http://dx.doi.org/10.1155/2014/857270
_version_ 1782315584853114880
author Pardo, María
Crujeiras, Ana B.
Amil, María
Aguera, Zaida
Jiménez-Murcia, Susana
Baños, Rosa
Botella, Cristina
de la Torre, Rafael
Estivill, Xavier
Fagundo, Ana B.
Fernández-Real, Jose M.
Fernández-García, José C.
Fruhbeck, Gema
Gómez-Ambrosi, Javier
Rodríguez, Roser
Tinahones, Francisco J.
Fernández-Aranda, Fernando
Casanueva, Felipe F.
author_facet Pardo, María
Crujeiras, Ana B.
Amil, María
Aguera, Zaida
Jiménez-Murcia, Susana
Baños, Rosa
Botella, Cristina
de la Torre, Rafael
Estivill, Xavier
Fagundo, Ana B.
Fernández-Real, Jose M.
Fernández-García, José C.
Fruhbeck, Gema
Gómez-Ambrosi, Javier
Rodríguez, Roser
Tinahones, Francisco J.
Fernández-Aranda, Fernando
Casanueva, Felipe F.
author_sort Pardo, María
collection PubMed
description FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor.
format Online
Article
Text
id pubmed-4016898
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-40168982014-05-26 Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index Pardo, María Crujeiras, Ana B. Amil, María Aguera, Zaida Jiménez-Murcia, Susana Baños, Rosa Botella, Cristina de la Torre, Rafael Estivill, Xavier Fagundo, Ana B. Fernández-Real, Jose M. Fernández-García, José C. Fruhbeck, Gema Gómez-Ambrosi, Javier Rodríguez, Roser Tinahones, Francisco J. Fernández-Aranda, Fernando Casanueva, Felipe F. Int J Endocrinol Research Article FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor. Hindawi Publishing Corporation 2014 2014-04-22 /pmc/articles/PMC4016898/ /pubmed/24864142 http://dx.doi.org/10.1155/2014/857270 Text en Copyright © 2014 María Pardo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Pardo, María
Crujeiras, Ana B.
Amil, María
Aguera, Zaida
Jiménez-Murcia, Susana
Baños, Rosa
Botella, Cristina
de la Torre, Rafael
Estivill, Xavier
Fagundo, Ana B.
Fernández-Real, Jose M.
Fernández-García, José C.
Fruhbeck, Gema
Gómez-Ambrosi, Javier
Rodríguez, Roser
Tinahones, Francisco J.
Fernández-Aranda, Fernando
Casanueva, Felipe F.
Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index
title Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index
title_full Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index
title_fullStr Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index
title_full_unstemmed Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index
title_short Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index
title_sort association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016898/
https://www.ncbi.nlm.nih.gov/pubmed/24864142
http://dx.doi.org/10.1155/2014/857270
work_keys_str_mv AT pardomaria associationofirisinwithfatmassrestingenergyexpenditureanddailyactivityinconditionsofextremebodymassindex
AT crujeirasanab associationofirisinwithfatmassrestingenergyexpenditureanddailyactivityinconditionsofextremebodymassindex
AT amilmaria associationofirisinwithfatmassrestingenergyexpenditureanddailyactivityinconditionsofextremebodymassindex
AT aguerazaida associationofirisinwithfatmassrestingenergyexpenditureanddailyactivityinconditionsofextremebodymassindex
AT jimenezmurciasusana associationofirisinwithfatmassrestingenergyexpenditureanddailyactivityinconditionsofextremebodymassindex
AT banosrosa associationofirisinwithfatmassrestingenergyexpenditureanddailyactivityinconditionsofextremebodymassindex
AT botellacristina associationofirisinwithfatmassrestingenergyexpenditureanddailyactivityinconditionsofextremebodymassindex
AT delatorrerafael associationofirisinwithfatmassrestingenergyexpenditureanddailyactivityinconditionsofextremebodymassindex
AT estivillxavier associationofirisinwithfatmassrestingenergyexpenditureanddailyactivityinconditionsofextremebodymassindex
AT fagundoanab associationofirisinwithfatmassrestingenergyexpenditureanddailyactivityinconditionsofextremebodymassindex
AT fernandezrealjosem associationofirisinwithfatmassrestingenergyexpenditureanddailyactivityinconditionsofextremebodymassindex
AT fernandezgarciajosec associationofirisinwithfatmassrestingenergyexpenditureanddailyactivityinconditionsofextremebodymassindex
AT fruhbeckgema associationofirisinwithfatmassrestingenergyexpenditureanddailyactivityinconditionsofextremebodymassindex
AT gomezambrosijavier associationofirisinwithfatmassrestingenergyexpenditureanddailyactivityinconditionsofextremebodymassindex
AT rodriguezroser associationofirisinwithfatmassrestingenergyexpenditureanddailyactivityinconditionsofextremebodymassindex
AT tinahonesfranciscoj associationofirisinwithfatmassrestingenergyexpenditureanddailyactivityinconditionsofextremebodymassindex
AT fernandezarandafernando associationofirisinwithfatmassrestingenergyexpenditureanddailyactivityinconditionsofextremebodymassindex
AT casanuevafelipef associationofirisinwithfatmassrestingenergyexpenditureanddailyactivityinconditionsofextremebodymassindex