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Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma
Purpose. Yes-associated protein (YAP) and PDZ-binding motif (TAZ) are two important effectors of Hippo pathway controlling the balance of organ size and carcinogenesis. Amphiregulin (AREG) is a member of the epidermal growth factor family, a direct target gene of YAP and TAZ. The role of these prote...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016924/ https://www.ncbi.nlm.nih.gov/pubmed/24860833 http://dx.doi.org/10.1155/2014/261365 |
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author | Han, Su-xia Bai, E. Jin, Gui-hua He, Chen-chen Guo, Xi-jing Wang, Li-juan Li, Meng Ying, Xia Zhu, Qing |
author_facet | Han, Su-xia Bai, E. Jin, Gui-hua He, Chen-chen Guo, Xi-jing Wang, Li-juan Li, Meng Ying, Xia Zhu, Qing |
author_sort | Han, Su-xia |
collection | PubMed |
description | Purpose. Yes-associated protein (YAP) and PDZ-binding motif (TAZ) are two important effectors of Hippo pathway controlling the balance of organ size and carcinogenesis. Amphiregulin (AREG) is a member of the epidermal growth factor family, a direct target gene of YAP and TAZ. The role of these proteins in hepatocellular carcinoma (HCC) is unclear. Methods. The expression of YAP, TAZ, and AREG in HCC was analyzed by immunohistochemical staining. The level of secreted serum AREG was also assayed by enzyme-linked immunosorbent (ELISA) assay. Results. YAP, TAZ, and AREG were expressed in 69.2% (27/39), 66.7% (26/39), and 61.5% (24/39) of HCC patients. The expression of YAP was significantly correlated with Edmondson stage (P > 0.05), serum AFP level (P > 0.05), and HCC prognosis (P > 0.05). AREG expression was also significantly correlated with Edmondson stage (P > 0.05) and serum AFP level (P > 0.05). In addition, the expression of serum AREG was higher than serum AFP in HCC patients. Further multivariate analysis showed that YAP expression was an independent prognostic factor that significantly affected the overall survival of HCC patients. Conclusions. YAP maybe an independent prognostic indicator for HCC patients and serum AREG may be a serological biomarker of HCC. |
format | Online Article Text |
id | pubmed-4016924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40169242014-05-25 Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma Han, Su-xia Bai, E. Jin, Gui-hua He, Chen-chen Guo, Xi-jing Wang, Li-juan Li, Meng Ying, Xia Zhu, Qing J Immunol Res Research Article Purpose. Yes-associated protein (YAP) and PDZ-binding motif (TAZ) are two important effectors of Hippo pathway controlling the balance of organ size and carcinogenesis. Amphiregulin (AREG) is a member of the epidermal growth factor family, a direct target gene of YAP and TAZ. The role of these proteins in hepatocellular carcinoma (HCC) is unclear. Methods. The expression of YAP, TAZ, and AREG in HCC was analyzed by immunohistochemical staining. The level of secreted serum AREG was also assayed by enzyme-linked immunosorbent (ELISA) assay. Results. YAP, TAZ, and AREG were expressed in 69.2% (27/39), 66.7% (26/39), and 61.5% (24/39) of HCC patients. The expression of YAP was significantly correlated with Edmondson stage (P > 0.05), serum AFP level (P > 0.05), and HCC prognosis (P > 0.05). AREG expression was also significantly correlated with Edmondson stage (P > 0.05) and serum AFP level (P > 0.05). In addition, the expression of serum AREG was higher than serum AFP in HCC patients. Further multivariate analysis showed that YAP expression was an independent prognostic factor that significantly affected the overall survival of HCC patients. Conclusions. YAP maybe an independent prognostic indicator for HCC patients and serum AREG may be a serological biomarker of HCC. Hindawi Publishing Corporation 2014 2014-04-22 /pmc/articles/PMC4016924/ /pubmed/24860833 http://dx.doi.org/10.1155/2014/261365 Text en Copyright © 2014 Su-xia Han et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Han, Su-xia Bai, E. Jin, Gui-hua He, Chen-chen Guo, Xi-jing Wang, Li-juan Li, Meng Ying, Xia Zhu, Qing Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma |
title | Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma |
title_full | Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma |
title_fullStr | Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma |
title_full_unstemmed | Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma |
title_short | Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma |
title_sort | expression and clinical significance of yap, taz, and areg in hepatocellular carcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016924/ https://www.ncbi.nlm.nih.gov/pubmed/24860833 http://dx.doi.org/10.1155/2014/261365 |
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