Mutations in epigenetic regulators including SETD2 are gained during relapse in pediatric acute lymphoblastic leukemia

Relapsed pediatric acute lymphoblastic leukemia (ALL) has high rates of treatment failure. Epigenetic regulators have been proposed as modulators of chemoresistance, here we sequence genes encoding epigenetic regulators in matched diagnosis-remission-relapse ALL samples. We find significant enrichme...

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Detalles Bibliográficos
Autores principales: Mar, Brenton G, Bullinger, Lars B, McLean, Kathleen M, Grauman, Peter V, Harris, Marian H, Stevenson, Kristen, Neuberg, Donna S, Sinha, Amit U, Sallan, Stephen E, Silverman, Lewis B, Kung, Andrew L, Nigro, Luca Lo, Ebert, Benjamin L, Armstrong, Scott A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016990/
https://www.ncbi.nlm.nih.gov/pubmed/24662245
http://dx.doi.org/10.1038/ncomms4469

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