Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair

SLX4 binds to three nucleases (XPF-ERCC1, MUS81-EME1, and SLX1), and its deficiency leads to genomic instability, sensitivity to DNA crosslinking agents, and Fanconi anemia. However, it is not understood how SLX4 and its associated nucleases act in DNA crosslink repair. Here, we uncover consequences...

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Detalles Bibliográficos
Autores principales: Hodskinson, Michael R.G., Silhan, Jan, Crossan, Gerry P., Garaycoechea, Juan I., Mukherjee, Shivam, Johnson, Christopher M., Schärer, Orlando D., Patel, Ketan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017094/
https://www.ncbi.nlm.nih.gov/pubmed/24726326
http://dx.doi.org/10.1016/j.molcel.2014.03.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017094/
https://www.ncbi.nlm.nih.gov/pubmed/24726326
http://dx.doi.org/10.1016/j.molcel.2014.03.014

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