Cargando…

Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair

SLX4 binds to three nucleases (XPF-ERCC1, MUS81-EME1, and SLX1), and its deficiency leads to genomic instability, sensitivity to DNA crosslinking agents, and Fanconi anemia. However, it is not understood how SLX4 and its associated nucleases act in DNA crosslink repair. Here, we uncover consequences...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hodskinson, Michael R.G., Silhan, Jan, Crossan, Gerry P., Garaycoechea, Juan I., Mukherjee, Shivam, Johnson, Christopher M., Schärer, Orlando D., Patel, Ketan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017094/ https://www.ncbi.nlm.nih.gov/pubmed/24726326 http://dx.doi.org/10.1016/j.molcel.2014.03.014

Ejemplares similares

SLX4IP acts with SLX4 and XPF–ERCC1 to promote interstrand crosslink repair
por: Zhang, Huimin, et al.
Publicado: (2019)

XPF–ERCC1: Linchpin of DNA crosslink repair
por: McHugh, Peter J.
Publicado: (2020)

Mislocalization of XPF-ERCC1 Nuclease Contributes to Reduced DNA Repair in XP-F Patients
por: Ahmad, Anwaar, et al.
Publicado: (2010)

XPF-ERCC1 protects liver, kidney and blood homeostasis outside the canonical excision repair pathways
por: Mulderrig, Lee, et al.
Publicado: (2020)

The role of SLX4 and its associated nucleases in DNA interstrand crosslink repair
por: Hoogenboom, Wouter S, et al.
Publicado: (2019)

Recruitment and positioning determine the specific role of the XPF‐ERCC1 endonuclease in interstrand crosslink repair
por: Klein Douwel, Daisy, et al.
Publicado: (2017)

Combinatorial Regulation of Meiotic Holliday Junction Resolution in C. elegans by HIM-6 (BLM) Helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 Nucleases
por: Agostinho, Ana, et al.
Publicado: (2013)

RPA activates the XPF‐ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks
por: Abdullah, Ummi B, et al.
Publicado: (2017)

ERCC1–XPF targeting to psoralen–DNA crosslinks depends on XPA and FANCD2
por: Sabatella, Mariangela, et al.
Publicado: (2019)

Correction: Combinatorial Regulation of Meiotic Holliday Junction Resolution in C. elegans by HIM-6 (BLM) Helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 Nucleases
por: Agostinho, Ana, et al.
Publicado: (2013)

Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression
por: Usanova, Svetlana, et al.
Publicado: (2010)

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi Anemia
por: Crossan, Gerry P., et al.
Publicado: (2011)

Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex
por: Yin, Jinhu, et al.
Publicado: (2016)

Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation
por: Wang, Jiajia, et al.
Publicado: (2020)

Recognition and processing of branched DNA substrates by Slx1–Slx4 nuclease
por: Gaur, Vineet, et al.
Publicado: (2019)

Distinct roles of XPF-ERCC1 and Rad1-Rad10-Saw1 in replication-coupled and uncoupled inter-strand crosslink repair
por: Seol, Ja-Hwan, et al.
Publicado: (2018)

Caenorhabditis elegans HIM-18/SLX-4 Interacts with SLX-1 and XPF-1 and Maintains Genomic Integrity in the Germline by Processing Recombination Intermediates
por: Saito, Takamune T., et al.
Publicado: (2009)

Function and Interactions of ERCC1-XPF in DNA Damage Response
por: Faridounnia, Maryam, et al.
Publicado: (2018)

Association of ERCC1 and XPF polymorphisms with pediatric glioma susceptibility
por: Chen, Yongping, et al.
Publicado: (2023)

ERCC1/XPF Is Important for Repair of DNA Double-Strand Breaks Containing Secondary Structures
por: Li, Shibo, et al.
Publicado: (2019)

Expression and Clinical Significance of ERCC1 and XPF in Human Hepatocellular Carcinoma
por: Liao, Xiaoli, et al.
Publicado: (2020)

SLX4–XPF mediates DNA damage responses to replication stress induced by DNA–protein interactions
por: Ishimoto, Riko, et al.
Publicado: (2020)

Synthesis of structurally diverse major groove DNA interstrand crosslinks using three different aldehyde precursors
por: Mukherjee, Shivam, et al.
Publicado: (2014)

DNA repair endonuclease ERCC1–XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy
por: McNeil, Ewan M., et al.
Publicado: (2012)

Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation
por: Talhaoui, Ibtissam, et al.
Publicado: (2018)

Computational Characterization of Small Molecules Binding to the Human XPF Active Site and Virtual Screening to Identify Potential New DNA Repair Inhibitors Targeting the ERCC1-XPF Endonuclease
por: Gentile, Francesco, et al.
Publicado: (2018)

Nuclease Delivery: Versatile Functions of SLX4/FANCP in Genome Maintenance
por: Kim, Yonghwan
Publicado: (2014)

Crossover recombination mediated by HIM-18/SLX4-associated nucleases
por: Saito, Takamune T, et al.
Publicado: (2014)

DNA end-directed and processive nuclease activities of the archaeal XPF enzyme
por: Roberts, Jennifer A., et al.
Publicado: (2005)

Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells
por: Arora, Sanjeevani, et al.
Publicado: (2016)

ERCC1/XPF Protects Short Telomeres from Homologous Recombination in Arabidopsis thaliana
por: Vannier, Jean-Baptiste, et al.
Publicado: (2009)

Polymorphisms in ERCC1 and XPF Genes and Risk of Gastric Cancer in an Eastern Chinese Population
por: He, Jing, et al.
Publicado: (2012)

Functional Polymorphisms at ERCC1/XPF Genes Confer Neuroblastoma Risk in Chinese Children
por: Zhuo, Zhen-Jian, et al.
Publicado: (2018)

Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases
por: Castor, Dennis, et al.
Publicado: (2013)

Exploring the Structures and Functions of Macromolecular SLX4-Nuclease Complexes in Genome Stability
por: Payliss, Brandon J., et al.
Publicado: (2021)

USP45 deubiquitylase controls ERCC1–XPF endonuclease-mediated DNA damage responses
por: Perez-Oliva, Ana B, et al.
Publicado: (2015)

The splicing factor XAB2 interacts with ERCC1-XPF and XPG for R-loop processing
por: Goulielmaki, Evi, et al.
Publicado: (2021)

The structure and duplex context of DNA interstrand crosslinks affects the activity of DNA polymerase η
por: Roy, Upasana, et al.
Publicado: (2016)

DNA crosslink repair safeguards genomic stability during pre-meiotic germ cell development
por: Hill, Ross J, et al.
Publicado: (2019)

Fanconi anemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mouse development
por: Bona, Nazareno, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5js7u1kvtueu1bmtbb63k9rqve