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Hematopoietic not systemic impairment of Roquin expression accounts for intestinal inflammation in Roquin-deficient mice

Roquin, an E3 ligase, is involved in curtailing autoimmune pathology as seen from studies using mice with mutated (Rc3h1(san/san)) or disrupted (Rc3h1(gt/gt)) Rc3h1 gene. The extent to which intestinal immunopathology is caused by insufficient Roquin expression in the immune system, or by Roquin imp...

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Detalles Bibliográficos
Autores principales:	Montufar-Solis, Dina, Vigneswaran, Nadarajah, Nakra, Niyati, Schaefer, Jeremy S., Klein, John R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017215/ https://www.ncbi.nlm.nih.gov/pubmed/24815331 http://dx.doi.org/10.1038/srep04920

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