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Molecular Basis and Regulation of OTULIN-LUBAC Interaction

The linear ubiquitin (Ub) chain assembly complex (LUBAC) generates Met1-linked “linear” Ub chains that regulate the activation of the nuclear factor κB (NFκB) transcription factor and other processes. We recently discovered OTULIN as a deubiquitinase that specifically cleaves Met1-linked polyUb. Now...

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Detalles Bibliográficos
Autores principales:	Elliott, Paul R., Nielsen, Sofie V., Marco-Casanova, Paola, Fiil, Berthe Katrine, Keusekotten, Kirstin, Mailand, Niels, Freund, Stefan M.V., Gyrd-Hansen, Mads, Komander, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017264/ https://www.ncbi.nlm.nih.gov/pubmed/24726323 http://dx.doi.org/10.1016/j.molcel.2014.03.018

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