Evaluation of salivary beta-2 microglobulin as HBV proliferation marker in HBS Ag(+), HBV DNA PCR(+) and HBV DNA PCR(−) subjects

AIM: The aim of this study was to determine the concentration of salivary B(2)M as a marker of viral proliferation in HBS Ag(+), HBV DNA PCR(+) and Hbs Ag(+) and HBV DNA PCR(−) subjects. BACKGROUND: Beta-2 microglobulin (B(2)M) is responsible for transmission of viral antigens such as Hepatitis B (HBV) on the surface of liver cells as part of an HLA complex. PATIENTS AND METHODS: In this case control study, 25 PCR(+) and 2 PCR(−) patients were included. 5 mL of the saliva sample was obtained from all patients and salivary B(2)M level was measured using nephelometer. The data was evaluated by the descriptive, chi square and t tests. RESULTS: 72% of the PCR(+) patients received medications and in contrast, 85.7% of the patients with PCR(−) did not take any medication (P < 0.001). The average salivary concentration ofBeta-2 microglobulin in the PCR(+) group (5.28 ± 5.45 mg/deciliter) was more than PCR(−) group (1.51±0.77) and this difference was statistically significant (P = 0.003). CONCLUSION: The salivary B(2)Mlevel can be used as a marker of viral proliferation in patients with hepatitis B.