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Protein-protein interaction networks (PPI) and complex diseases
The physical interaction of proteins which lead to compiling them into large densely connected networks is a noticeable subject to investigation. Protein interaction networks are useful because of making basic scientific abstraction and improving biological and biomedical applications. Based on prin...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Institute for Gastroenterology and Liver Diseases
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017556/ https://www.ncbi.nlm.nih.gov/pubmed/25436094 |
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author | Safari-Alighiarloo, Nahid Taghizadeh, Mohammad Rezaei-Tavirani, Mostafa Goliaei, Bahram Peyvandi, Ali Asghar |
author_facet | Safari-Alighiarloo, Nahid Taghizadeh, Mohammad Rezaei-Tavirani, Mostafa Goliaei, Bahram Peyvandi, Ali Asghar |
author_sort | Safari-Alighiarloo, Nahid |
collection | PubMed |
description | The physical interaction of proteins which lead to compiling them into large densely connected networks is a noticeable subject to investigation. Protein interaction networks are useful because of making basic scientific abstraction and improving biological and biomedical applications. Based on principle roles of proteins in biological function, their interactions determine molecular and cellular mechanisms, which control healthy and diseased states in organisms. Therefore, such networks facilitate the understanding of pathogenic (and physiologic) mechanisms that trigger the onset and progression of diseases. Consequently, this knowledge can be translated into effective diagnostic and therapeutic strategies. Furthermore, the results of several studies have proved that the structure and dynamics of protein networks are disturbed in complex diseases such as cancer and autoimmune disorders. Based on such relationship, a novel paradigm is suggested in order to confirm that the protein interaction networks can be the target of therapy for treatment of complex multi-genic diseases rather than individual molecules with disrespect the network. |
format | Online Article Text |
id | pubmed-4017556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Research Institute for Gastroenterology and Liver Diseases |
record_format | MEDLINE/PubMed |
spelling | pubmed-40175562014-12-01 Protein-protein interaction networks (PPI) and complex diseases Safari-Alighiarloo, Nahid Taghizadeh, Mohammad Rezaei-Tavirani, Mostafa Goliaei, Bahram Peyvandi, Ali Asghar Gastroenterol Hepatol Bed Bench Review Article The physical interaction of proteins which lead to compiling them into large densely connected networks is a noticeable subject to investigation. Protein interaction networks are useful because of making basic scientific abstraction and improving biological and biomedical applications. Based on principle roles of proteins in biological function, their interactions determine molecular and cellular mechanisms, which control healthy and diseased states in organisms. Therefore, such networks facilitate the understanding of pathogenic (and physiologic) mechanisms that trigger the onset and progression of diseases. Consequently, this knowledge can be translated into effective diagnostic and therapeutic strategies. Furthermore, the results of several studies have proved that the structure and dynamics of protein networks are disturbed in complex diseases such as cancer and autoimmune disorders. Based on such relationship, a novel paradigm is suggested in order to confirm that the protein interaction networks can be the target of therapy for treatment of complex multi-genic diseases rather than individual molecules with disrespect the network. Research Institute for Gastroenterology and Liver Diseases 2014 /pmc/articles/PMC4017556/ /pubmed/25436094 Text en Copyright © 2014 Research Institute for Gastroenterology and Liver Diseases http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Review Article Safari-Alighiarloo, Nahid Taghizadeh, Mohammad Rezaei-Tavirani, Mostafa Goliaei, Bahram Peyvandi, Ali Asghar Protein-protein interaction networks (PPI) and complex diseases |
title | Protein-protein interaction networks (PPI) and complex diseases |
title_full | Protein-protein interaction networks (PPI) and complex diseases |
title_fullStr | Protein-protein interaction networks (PPI) and complex diseases |
title_full_unstemmed | Protein-protein interaction networks (PPI) and complex diseases |
title_short | Protein-protein interaction networks (PPI) and complex diseases |
title_sort | protein-protein interaction networks (ppi) and complex diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017556/ https://www.ncbi.nlm.nih.gov/pubmed/25436094 |
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