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Neo-adjuvant chemoradiotherapy; an opportunity in sphincter preserving procedure for rectal cancer

AIM: The present study was designed to assess the impact of neo-adjuvant chemoradiotherapy on the possibility of utilizing sphincter preserving techniques in rectal cancer surgery. BACKGROUND: For both patients and surgeons anal sphincter preserving surgery serves as the ideal procedure to treat rec...

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Autores principales: Mozafar, Mohammad, Adhami, Farideh, Atqiaee, Khashayar, Lotfollahzadeh, Saran, Sobhiyeh, Mohammad Reza, Amraei, Razie, Baikpour, Maryam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Institute for Gastroenterology and Liver Diseases 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017558/
https://www.ncbi.nlm.nih.gov/pubmed/25436095
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author Mozafar, Mohammad
Adhami, Farideh
Atqiaee, Khashayar
Lotfollahzadeh, Saran
Sobhiyeh, Mohammad Reza
Amraei, Razie
Baikpour, Maryam
author_facet Mozafar, Mohammad
Adhami, Farideh
Atqiaee, Khashayar
Lotfollahzadeh, Saran
Sobhiyeh, Mohammad Reza
Amraei, Razie
Baikpour, Maryam
author_sort Mozafar, Mohammad
collection PubMed
description AIM: The present study was designed to assess the impact of neo-adjuvant chemoradiotherapy on the possibility of utilizing sphincter preserving techniques in rectal cancer surgery. BACKGROUND: For both patients and surgeons anal sphincter preserving surgery serves as the ideal procedure to treat rectal cancer. PATIENTS AND METHODS: Patients with rectal cancer who were admitted to Shohadaye Tajrish hospital between 2001 and 2011 and underwent sphincter preserving or non-preserving surgery were identified. They were divided into those who had received neo-adjuvant chemo-radiotherapy prior to surgery and those who didn't, and the type of surgical procedure they underwent was compared between the two arms. Data regarding tumor pathology, tumor size and distance from anal verge before and after neo-adjuvant therapy, together with the duration of chemo-radiotherapy were also assessed. RESULTS: 103 patients with documented rectal cancer were included in our analysis. Among 47 patients who had not received neo-adjuvant therapy, 26 (55%) underwent APR while 15(32%) and 6(13%) patients were treated with LAR and VLAR respectively. Of the 56 patients who had gone through chemo-radiotherapy prior to surgery, 30 (53%) underwent APR while 14 (25%) and 10 (18%) patients were treated with LAR and VLAR respectively. 2 patients had unresectable tumor. Tumor staging before and after neo-adjuvant therapy showed a statistically significant difference (p=0.0001). CONCLUSION: Neo-adjuvant chemo-radiotherpy can decrease tumor size, increase the distance between the tumor and anal verge, and downgrade the staging. However, it does not necessarily increase the possibility of performing sphincter preserving surgery on patients suffering from low-lying tumors.
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spelling pubmed-40175582014-12-01 Neo-adjuvant chemoradiotherapy; an opportunity in sphincter preserving procedure for rectal cancer Mozafar, Mohammad Adhami, Farideh Atqiaee, Khashayar Lotfollahzadeh, Saran Sobhiyeh, Mohammad Reza Amraei, Razie Baikpour, Maryam Gastroenterol Hepatol Bed Bench Original Article AIM: The present study was designed to assess the impact of neo-adjuvant chemoradiotherapy on the possibility of utilizing sphincter preserving techniques in rectal cancer surgery. BACKGROUND: For both patients and surgeons anal sphincter preserving surgery serves as the ideal procedure to treat rectal cancer. PATIENTS AND METHODS: Patients with rectal cancer who were admitted to Shohadaye Tajrish hospital between 2001 and 2011 and underwent sphincter preserving or non-preserving surgery were identified. They were divided into those who had received neo-adjuvant chemo-radiotherapy prior to surgery and those who didn't, and the type of surgical procedure they underwent was compared between the two arms. Data regarding tumor pathology, tumor size and distance from anal verge before and after neo-adjuvant therapy, together with the duration of chemo-radiotherapy were also assessed. RESULTS: 103 patients with documented rectal cancer were included in our analysis. Among 47 patients who had not received neo-adjuvant therapy, 26 (55%) underwent APR while 15(32%) and 6(13%) patients were treated with LAR and VLAR respectively. Of the 56 patients who had gone through chemo-radiotherapy prior to surgery, 30 (53%) underwent APR while 14 (25%) and 10 (18%) patients were treated with LAR and VLAR respectively. 2 patients had unresectable tumor. Tumor staging before and after neo-adjuvant therapy showed a statistically significant difference (p=0.0001). CONCLUSION: Neo-adjuvant chemo-radiotherpy can decrease tumor size, increase the distance between the tumor and anal verge, and downgrade the staging. However, it does not necessarily increase the possibility of performing sphincter preserving surgery on patients suffering from low-lying tumors. Research Institute for Gastroenterology and Liver Diseases 2014 /pmc/articles/PMC4017558/ /pubmed/25436095 Text en Copyright © 2014 Research Institute for Gastroenterology and Liver Diseases http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Mozafar, Mohammad
Adhami, Farideh
Atqiaee, Khashayar
Lotfollahzadeh, Saran
Sobhiyeh, Mohammad Reza
Amraei, Razie
Baikpour, Maryam
Neo-adjuvant chemoradiotherapy; an opportunity in sphincter preserving procedure for rectal cancer
title Neo-adjuvant chemoradiotherapy; an opportunity in sphincter preserving procedure for rectal cancer
title_full Neo-adjuvant chemoradiotherapy; an opportunity in sphincter preserving procedure for rectal cancer
title_fullStr Neo-adjuvant chemoradiotherapy; an opportunity in sphincter preserving procedure for rectal cancer
title_full_unstemmed Neo-adjuvant chemoradiotherapy; an opportunity in sphincter preserving procedure for rectal cancer
title_short Neo-adjuvant chemoradiotherapy; an opportunity in sphincter preserving procedure for rectal cancer
title_sort neo-adjuvant chemoradiotherapy; an opportunity in sphincter preserving procedure for rectal cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017558/
https://www.ncbi.nlm.nih.gov/pubmed/25436095
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