Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes

[Image: see text] We have developed an automated photochemical microfluidics platform that integrates a 1 kW high-pressure Hg vapor lamp and allows for analytical pulse flow or preparative continuous flow reactions. Herein, we will discuss the use of this platform toward the discovery of new chemoty...

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Autores principales: Martin, Véronique I., Goodell, John R., Ingham, Oscar J., Porco, John A., Beeler, Aaron B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017617/
https://www.ncbi.nlm.nih.gov/pubmed/24697145
http://dx.doi.org/10.1021/jo500190b
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author Martin, Véronique I.
Goodell, John R.
Ingham, Oscar J.
Porco, John A.
Beeler, Aaron B.
author_facet Martin, Véronique I.
Goodell, John R.
Ingham, Oscar J.
Porco, John A.
Beeler, Aaron B.
author_sort Martin, Véronique I.
collection PubMed
description [Image: see text] We have developed an automated photochemical microfluidics platform that integrates a 1 kW high-pressure Hg vapor lamp and allows for analytical pulse flow or preparative continuous flow reactions. Herein, we will discuss the use of this platform toward the discovery of new chemotypes through multidimensional reaction screening. We will highlight the ability to discretely control wavelengths with optical filters, allowing for control of reaction outcomes.
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spelling pubmed-40176172015-04-03 Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes Martin, Véronique I. Goodell, John R. Ingham, Oscar J. Porco, John A. Beeler, Aaron B. J Org Chem [Image: see text] We have developed an automated photochemical microfluidics platform that integrates a 1 kW high-pressure Hg vapor lamp and allows for analytical pulse flow or preparative continuous flow reactions. Herein, we will discuss the use of this platform toward the discovery of new chemotypes through multidimensional reaction screening. We will highlight the ability to discretely control wavelengths with optical filters, allowing for control of reaction outcomes. American Chemical Society 2014-04-03 2014-05-02 /pmc/articles/PMC4017617/ /pubmed/24697145 http://dx.doi.org/10.1021/jo500190b Text en Copyright © 2014 American Chemical Society
spellingShingle Martin, Véronique I.
Goodell, John R.
Ingham, Oscar J.
Porco, John A.
Beeler, Aaron B.
Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes
title Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes
title_full Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes
title_fullStr Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes
title_full_unstemmed Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes
title_short Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes
title_sort multidimensional reaction screening for photochemical transformations as a tool for discovering new chemotypes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017617/
https://www.ncbi.nlm.nih.gov/pubmed/24697145
http://dx.doi.org/10.1021/jo500190b
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AT porcojohna multidimensionalreactionscreeningforphotochemicaltransformationsasatoolfordiscoveringnewchemotypes
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