Cargando…
Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network
Resveratrol has beneficial effects on aging, inflammation and metabolism, which are thought to result from activation of the lysine deacetylase, sirtuin 1 (SIRT1), the cAMP pathway, or AMP-activated protein kinase. In this study, we report that resveratrol acts as a pathway-selective estrogen recept...
Autores principales: | Nwachukwu, Jerome C, Srinivasan, Sathish, Bruno, Nelson E, Parent, Alexander A, Hughes, Travis S, Pollock, Julie A, Gjyshi, Olsi, Cavett, Valerie, Nowak, Jason, Garcia-Ordonez, Ruben D, Houtman, René, Griffin, Patrick R, Kojetin, Douglas J, Katzenellenbogen, John A, Conkright, Michael D, Nettles, Kendall W |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017646/ https://www.ncbi.nlm.nih.gov/pubmed/24771768 http://dx.doi.org/10.7554/eLife.02057 |
Ejemplares similares
-
Ligand-binding dynamics rewire cellular signaling via Estrogen Receptor-α
por: Srinivasan, Sathish, et al.
Publicado: (2013) -
Full Antagonism of the Estrogen Receptor without a Prototypical Ligand Side Chain
por: Srinivasan, Sathish, et al.
Publicado: (2016) -
Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes
por: Weikum, Emily R., et al.
Publicado: (2017) -
Predictive features of ligand‐specific signaling through the estrogen receptor
por: Nwachukwu, Jerome C, et al.
Publicado: (2016) -
OR12-07 Full Antagonism of Breast Cancer Cell Proliferation Can Result from Many Ligand-Induced Conformational Distortions of the Estrogen Receptor Ligand Binding Domain
por: Nwachukwu, Jerome, et al.
Publicado: (2020)