Cargando…
Genetic interactions affecting human gene expression identified by variance association mapping
Non-additive interaction between genetic variants, or epistasis, is a possible explanation for the gap between heritability of complex traits and the variation explained by identified genetic loci. Interactions give rise to genotype dependent variance, and therefore the identification of variance qu...
Autores principales: | Brown, Andrew Anand, Buil, Alfonso, Viñuela, Ana, Lappalainen, Tuuli, Zheng, Hou-Feng, Richards, J Brent, Small, Kerrin S, Spector, Timothy D, Dermitzakis, Emmanouil T, Durbin, Richard |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017648/ https://www.ncbi.nlm.nih.gov/pubmed/24771767 http://dx.doi.org/10.7554/eLife.01381 |
Ejemplares similares
-
Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort
por: Viñuela, Ana, et al.
Publicado: (2018) -
A high-resolution map of transcriptional repression
por: Liang, Ziwei, et al.
Publicado: (2017) -
Nuclear genetic regulation of the human mitochondrial transcriptome
por: Ali, Aminah T, et al.
Publicado: (2019) -
A map of directional genetic interactions in a metazoan cell
por: Fischer, Bernd, et al.
Publicado: (2015) -
An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites
por: Skene, Peter J, et al.
Publicado: (2017)