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None-endoscopic Screening for Esophageal Squamous Cell Carcinoma- A Review

Esophageal cancer (EC) is the eighth most common cancer and sixth most frequent cause of cancer mortality worldwide. Esophageal squamous cell carcinoma (ESCC) is the most common type of EC. ESCC develops by progression from premalignant lesions, which are called esophageal squamous dysplasia (ESD)....

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Autores principales: Roshandel, Gholamreza, Semnani, Shahryar, Malekzadeh, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Association of Gastroerterology and Hepatology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017690/
https://www.ncbi.nlm.nih.gov/pubmed/24829644
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author Roshandel, Gholamreza
Semnani, Shahryar
Malekzadeh, Reza
author_facet Roshandel, Gholamreza
Semnani, Shahryar
Malekzadeh, Reza
author_sort Roshandel, Gholamreza
collection PubMed
description Esophageal cancer (EC) is the eighth most common cancer and sixth most frequent cause of cancer mortality worldwide. Esophageal squamous cell carcinoma (ESCC) is the most common type of EC. ESCC develops by progression from premalignant lesions, which are called esophageal squamous dysplasia (ESD). Prevention is the most effective strategy for controlling this disease. Generally, two methods may be defined for ESCC prevention. The aim of the first preventive method is to prevent the initiation of ESD by avoiding the known risk factors, or primary prevention. Secondary prevention focuses on detection of the disease in its early curable stage, thus preventing its progression into advanced stages. Endoscopy with iodine staining and biopsy is the diagnostic choice for ESD. However it is invasive and expensive, and not accepted by asymptomatic ESD cases. Therefore, it is necessary to find a non-endoscopic screening method. Despite the large number of studies conducted worldwide, no approved method has been developed for ESCC screening. Regarding the multi-factorial nature of ESCC, it is proposed that the use of a combination of various criteria, such as cytological examination, risk factors, genetic alteration, and molecular markers may result in the development of a comprehensive and effective ESCC screening program.
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spelling pubmed-40176902014-05-14 None-endoscopic Screening for Esophageal Squamous Cell Carcinoma- A Review Roshandel, Gholamreza Semnani, Shahryar Malekzadeh, Reza Middle East J Dig Dis Systematic Review Esophageal cancer (EC) is the eighth most common cancer and sixth most frequent cause of cancer mortality worldwide. Esophageal squamous cell carcinoma (ESCC) is the most common type of EC. ESCC develops by progression from premalignant lesions, which are called esophageal squamous dysplasia (ESD). Prevention is the most effective strategy for controlling this disease. Generally, two methods may be defined for ESCC prevention. The aim of the first preventive method is to prevent the initiation of ESD by avoiding the known risk factors, or primary prevention. Secondary prevention focuses on detection of the disease in its early curable stage, thus preventing its progression into advanced stages. Endoscopy with iodine staining and biopsy is the diagnostic choice for ESD. However it is invasive and expensive, and not accepted by asymptomatic ESD cases. Therefore, it is necessary to find a non-endoscopic screening method. Despite the large number of studies conducted worldwide, no approved method has been developed for ESCC screening. Regarding the multi-factorial nature of ESCC, it is proposed that the use of a combination of various criteria, such as cytological examination, risk factors, genetic alteration, and molecular markers may result in the development of a comprehensive and effective ESCC screening program. Iranian Association of Gastroerterology and Hepatology 2012-04 /pmc/articles/PMC4017690/ /pubmed/24829644 Text en © 2012 by Middle East Journal of Digestive Diseases This work is published by Middle East Journal of Digestive Diseases as an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-sa/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Systematic Review
Roshandel, Gholamreza
Semnani, Shahryar
Malekzadeh, Reza
None-endoscopic Screening for Esophageal Squamous Cell Carcinoma- A Review
title None-endoscopic Screening for Esophageal Squamous Cell Carcinoma- A Review
title_full None-endoscopic Screening for Esophageal Squamous Cell Carcinoma- A Review
title_fullStr None-endoscopic Screening for Esophageal Squamous Cell Carcinoma- A Review
title_full_unstemmed None-endoscopic Screening for Esophageal Squamous Cell Carcinoma- A Review
title_short None-endoscopic Screening for Esophageal Squamous Cell Carcinoma- A Review
title_sort none-endoscopic screening for esophageal squamous cell carcinoma- a review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017690/
https://www.ncbi.nlm.nih.gov/pubmed/24829644
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