Septic arthritis: immunopathogenesis, experimental models and therapy

Septic arthritis is an inflammatory disease of the joints that is started by an infection whose most common agent is Staphylococcus aureus. In this review we discuss some of the most arthritogenic bacterial factors and the contribution of innate and specific immune mechanisms to joint destruction. S...

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Detalles Bibliográficos
Autores principales: Colavite, Priscila Maria, Sartori, Alexandrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017707/
https://www.ncbi.nlm.nih.gov/pubmed/24822058
http://dx.doi.org/10.1186/1678-9199-20-19
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author Colavite, Priscila Maria
Sartori, Alexandrina
author_facet Colavite, Priscila Maria
Sartori, Alexandrina
author_sort Colavite, Priscila Maria
collection PubMed
description Septic arthritis is an inflammatory disease of the joints that is started by an infection whose most common agent is Staphylococcus aureus. In this review we discuss some of the most arthritogenic bacterial factors and the contribution of innate and specific immune mechanisms to joint destruction. Special emphasis is given to the induction of experimental arthritis by S. aureus in mice. The improvement of therapy by association of antibiotics with down-modulation of immunity is also included.
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spelling pubmed-40177072014-05-13 Septic arthritis: immunopathogenesis, experimental models and therapy Colavite, Priscila Maria Sartori, Alexandrina J Venom Anim Toxins Incl Trop Dis Review Septic arthritis is an inflammatory disease of the joints that is started by an infection whose most common agent is Staphylococcus aureus. In this review we discuss some of the most arthritogenic bacterial factors and the contribution of innate and specific immune mechanisms to joint destruction. Special emphasis is given to the induction of experimental arthritis by S. aureus in mice. The improvement of therapy by association of antibiotics with down-modulation of immunity is also included. BioMed Central 2014-05-06 /pmc/articles/PMC4017707/ /pubmed/24822058 http://dx.doi.org/10.1186/1678-9199-20-19 Text en Copyright © 2014 Colavite and Sartori; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Colavite, Priscila Maria
Sartori, Alexandrina
Septic arthritis: immunopathogenesis, experimental models and therapy
title Septic arthritis: immunopathogenesis, experimental models and therapy
title_full Septic arthritis: immunopathogenesis, experimental models and therapy
title_fullStr Septic arthritis: immunopathogenesis, experimental models and therapy
title_full_unstemmed Septic arthritis: immunopathogenesis, experimental models and therapy
title_short Septic arthritis: immunopathogenesis, experimental models and therapy
title_sort septic arthritis: immunopathogenesis, experimental models and therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017707/
https://www.ncbi.nlm.nih.gov/pubmed/24822058
http://dx.doi.org/10.1186/1678-9199-20-19
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