Therapeutic Efficacy of Potent Neutralizing HIV-1-Specific Monoclonal Antibodies in SHIV-Infected Rhesus Monkeys

HIV-1-specific monoclonal antibodies (mAbs) with extraordinary potency and breadth have recently been described. In humanized mice, combinations of mAbs have been shown to suppress viremia, but the therapeutic potential of these mAbs has not yet been evaluated in primates with an intact immune syste...

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Detalles Bibliográficos
Autores principales: Barouch, Dan H., Whitney, James B., Moldt, Brian, Klein, Florian, Oliveira, Thiago Y., Liu, Jinyan, Stephenson, Kathryn E., Chang, Hui-Wen, Shekhar, Karthik, Gupta, Sanjana, Nkolola, Joseph P., Seaman, Michael S., Smith, Kaitlin M., Borducchi, Erica N., Cabral, Crystal, Smith, Jeffrey Y., Blackmore, Stephen, Sanisetty, Srisowmya, Perry, James R., Beck, Matthew, Lewis, Mark G., Rinaldi, William, Chakraborty, Arup K., Poignard, Pascal, Nussenzweig, Michel C., Burton, Dennis R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017780/
https://www.ncbi.nlm.nih.gov/pubmed/24172905
http://dx.doi.org/10.1038/nature12744

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