Linking a genetic defect in migraine to spreading depression in a computational model

Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura. A mutation causing FHM type 3 (FHM3) has been identified in SCN1A encoding the Nav1.1 Na(+) channel. This genetic defect affects the inactivation gate. While the Na(+) tail currents following voltage steps are consistent wit...

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Detalles Bibliográficos
Autores principales: Dahlem, Markus A., Schumacher, Julia, Hübel, Niklas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2014
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017887/
https://www.ncbi.nlm.nih.gov/pubmed/24860703
http://dx.doi.org/10.7717/peerj.379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017887/
https://www.ncbi.nlm.nih.gov/pubmed/24860703
http://dx.doi.org/10.7717/peerj.379

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