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Correlations between Integrin ανβ6 Expression and Clinico-Pathological Features in Stage B and Stage C Rectal Cancer

Integrin ανβ6 is highly expressed in a range of human cancers and frequently correlates with patient survival. This study examines correlations between ανβ6 expression and patient clinico-pathological features in Stage B and Stage C rectal cancer, including overall survival. Expression of ανβ6 was m...

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Autores principales: Ahn, Seong Beom, Mohamedali, Abidali, Chan, Charles, Fletcher, Julie, Kwun, Sun Young, Clarke, Candice, Dent, Owen F., Chapuis, Pierre H., Nice, Edouard, Baker, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018280/
https://www.ncbi.nlm.nih.gov/pubmed/24821188
http://dx.doi.org/10.1371/journal.pone.0097248
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author Ahn, Seong Beom
Mohamedali, Abidali
Chan, Charles
Fletcher, Julie
Kwun, Sun Young
Clarke, Candice
Dent, Owen F.
Chapuis, Pierre H.
Nice, Edouard
Baker, Mark S.
author_facet Ahn, Seong Beom
Mohamedali, Abidali
Chan, Charles
Fletcher, Julie
Kwun, Sun Young
Clarke, Candice
Dent, Owen F.
Chapuis, Pierre H.
Nice, Edouard
Baker, Mark S.
author_sort Ahn, Seong Beom
collection PubMed
description Integrin ανβ6 is highly expressed in a range of human cancers and frequently correlates with patient survival. This study examines correlations between ανβ6 expression and patient clinico-pathological features in Stage B and Stage C rectal cancer, including overall survival. Expression of ανβ6 was measured in 362 Stage B or C rectal cancer tissue samples at the tumour central region, invasive tumour front and adjacent non-neoplastic mucosa using immunohistochemistry. Distribution of ανβ6 was found to be significantly higher at the invasive front compared to central regions of the tumour (p<0.001) or adjacent non-neoplastic mucosa (p<0.001) suggesting ανβ6 plays a role in tumour cell invasion. However, integrin ανβ6 expression was not associated with clinico-pathological features or overall survival indicating it is not an independent prognostic marker differentiating Stage B or C rectal cancer. Previous ανβ6 studies have suggested the expression of ανβ6 is involved in the earlier stages (i.e. Stages A/B) of tumour progression rather than the later stages (i.e. Stages C/D). However, our study has revealed that in rectal cancer ανβ6 expression does not increase between Stages B and C, but may occur earlier, namely before or during Stage B cancer.
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spelling pubmed-40182802014-05-16 Correlations between Integrin ανβ6 Expression and Clinico-Pathological Features in Stage B and Stage C Rectal Cancer Ahn, Seong Beom Mohamedali, Abidali Chan, Charles Fletcher, Julie Kwun, Sun Young Clarke, Candice Dent, Owen F. Chapuis, Pierre H. Nice, Edouard Baker, Mark S. PLoS One Research Article Integrin ανβ6 is highly expressed in a range of human cancers and frequently correlates with patient survival. This study examines correlations between ανβ6 expression and patient clinico-pathological features in Stage B and Stage C rectal cancer, including overall survival. Expression of ανβ6 was measured in 362 Stage B or C rectal cancer tissue samples at the tumour central region, invasive tumour front and adjacent non-neoplastic mucosa using immunohistochemistry. Distribution of ανβ6 was found to be significantly higher at the invasive front compared to central regions of the tumour (p<0.001) or adjacent non-neoplastic mucosa (p<0.001) suggesting ανβ6 plays a role in tumour cell invasion. However, integrin ανβ6 expression was not associated with clinico-pathological features or overall survival indicating it is not an independent prognostic marker differentiating Stage B or C rectal cancer. Previous ανβ6 studies have suggested the expression of ανβ6 is involved in the earlier stages (i.e. Stages A/B) of tumour progression rather than the later stages (i.e. Stages C/D). However, our study has revealed that in rectal cancer ανβ6 expression does not increase between Stages B and C, but may occur earlier, namely before or during Stage B cancer. Public Library of Science 2014-05-12 /pmc/articles/PMC4018280/ /pubmed/24821188 http://dx.doi.org/10.1371/journal.pone.0097248 Text en © 2014 Ahn et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Ahn, Seong Beom
Mohamedali, Abidali
Chan, Charles
Fletcher, Julie
Kwun, Sun Young
Clarke, Candice
Dent, Owen F.
Chapuis, Pierre H.
Nice, Edouard
Baker, Mark S.
Correlations between Integrin ανβ6 Expression and Clinico-Pathological Features in Stage B and Stage C Rectal Cancer
title Correlations between Integrin ανβ6 Expression and Clinico-Pathological Features in Stage B and Stage C Rectal Cancer
title_full Correlations between Integrin ανβ6 Expression and Clinico-Pathological Features in Stage B and Stage C Rectal Cancer
title_fullStr Correlations between Integrin ανβ6 Expression and Clinico-Pathological Features in Stage B and Stage C Rectal Cancer
title_full_unstemmed Correlations between Integrin ανβ6 Expression and Clinico-Pathological Features in Stage B and Stage C Rectal Cancer
title_short Correlations between Integrin ανβ6 Expression and Clinico-Pathological Features in Stage B and Stage C Rectal Cancer
title_sort correlations between integrin ανβ6 expression and clinico-pathological features in stage b and stage c rectal cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018280/
https://www.ncbi.nlm.nih.gov/pubmed/24821188
http://dx.doi.org/10.1371/journal.pone.0097248
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