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Long-Term Increased Carnitine Palmitoyltransferase 1A Expression in Ventromedial Hypotalamus Causes Hyperphagia and Alters the Hypothalamic Lipidomic Profile
Lipid metabolism in the ventromedial hypothalamus (VMH) has emerged as a crucial pathway in the regulation of feeding and energy homeostasis. Carnitine palmitoyltransferase (CPT) 1A is the rate-limiting enzyme in mitochondrial fatty acid β-oxidation and it has been proposed as a crucial mediator of...
Autores principales: | Mera, Paula, Mir, Joan Francesc, Fabriàs, Gemma, Casas, Josefina, Costa, Ana S. H., Malandrino, Maria Ida, Fernández-López, José-Antonio, Remesar, Xavier, Gao, Su, Chohnan, Shigeru, Rodríguez-Peña, Maria Sol, Petry, Harald, Asins, Guillermina, Hegardt, Fausto G., Herrero, Laura, Serra, Dolors |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018328/ https://www.ncbi.nlm.nih.gov/pubmed/24819600 http://dx.doi.org/10.1371/journal.pone.0097195 |
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