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Addressing RNA Integrity to Determine the Impact of Mitochondrial DNA Mutations on Brain Mitochondrial Function with Age

Mitochondrial DNA (mtDNA) mutations can result in mitochondrial dysfunction, but emerging experimental data question the fundamental role of mtDNA mutagenesis in age-associated mitochondrial impairment. The multicopy nature of mtDNA renders the impact of a given mtDNA mutation unpredictable. In this...

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Detalles Bibliográficos
Autores principales:	Wang, Wei, Scheffler, Katja, Esbensen, Ying, Strand, Janne M., Stewart, James B., Bjørås, Magnar, Eide, Lars
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018447/ https://www.ncbi.nlm.nih.gov/pubmed/24819950 http://dx.doi.org/10.1371/journal.pone.0096940

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