Cargando…

GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans

AIMS/HYPOTHESIS: The NEFA-responsive G-protein coupled receptor 120 (GPR120) has been implicated in the regulation of inflammation, in the control of incretin secretion and as a predisposing factor influencing the development of type 2 diabetes by regulation of islet cell apoptosis. However, there i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stone, Virginia M., Dhayal, Shalinee, Brocklehurst, Katy J., Lenaghan, Carol, Sörhede Winzell, Maria, Hammar, Mårten, Xu, Xiufeng, Smith, David M., Morgan, Noel G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018485/ https://www.ncbi.nlm.nih.gov/pubmed/24663807 http://dx.doi.org/10.1007/s00125-014-3213-0

Ejemplares similares

EPA Prevents the Development of Abdominal Aortic Aneurysms through Gpr-120/Ffar-4
por: Kamata, Ryo, et al.
Publicado: (2016)

Disturbed α-Cell Function in Mice with β-Cell Specific Overexpression of Human Islet Amyloid Polypeptide
por: Ahrén, Bo, et al.
Publicado: (2008)

Autocrine negative feedback regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT
por: Husted, Anna Sofie, et al.
Publicado: (2020)

The molecular mechanism of phytosphingosine binding to FFAR4/GPR120 differs from that of other fatty acids
por: Nagasawa, Tomotaka, et al.
Publicado: (2021)

GPR120/FFAR4 Pharmacology: Focus on Agonists in Type 2 Diabetes Mellitus Drug Discovery
por: Carullo, Gabriele, et al.
Publicado: (2021)

Polymorphisms in FFAR4 (GPR120) Gene Modulate Insulin Levels and Sensitivity after Fish Oil Supplementation
por: Vallée Marcotte, Bastien, et al.
Publicado: (2017)

The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1
por: Sundström, Linda, et al.
Publicado: (2017)

FFAR4 (GPR120) Signaling Is Not Required for Anti-Inflammatory and Insulin-Sensitizing Effects of Omega-3 Fatty Acids
por: Pærregaard, Simone Isling, et al.
Publicado: (2016)

Inhibition of the prostaglandin D(2)–GPR44/DP2 axis improves human islet survival and function
por: Abadpour, Shadab, et al.
Publicado: (2020)

Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion
por: Kristinsson, H., et al.
Publicado: (2017)

Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice
por: Nakamoto, Kazuo, et al.
Publicado: (2017)

Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1
por: Lückmann, Michael, et al.
Publicado: (2019)

The Cells of the Islets of Langerhans
por: Da Silva Xavier, Gabriela
Publicado: (2018)

Microwell Scaffolds for the Extrahepatic Transplantation of Islets of Langerhans
por: Buitinga, Mijke, et al.
Publicado: (2013)

Evaluation of the hepatotoxicity of the novel GPR40 (FFAR1) agonist CPL207280 in the rat and monkey
por: Bazydlo-Guzenda, Katarzyna, et al.
Publicado: (2021)

Layered PEGDA hydrogel for islet of Langerhans encapsulation and improvement of vascularization
por: Marchioli, Giulia, et al.
Publicado: (2017)

Inhibition of SGLT2 Preserves Function and Promotes Proliferation of Human Islets Cells In Vivo in Diabetic Mice
por: Karlsson, Daniel, et al.
Publicado: (2022)

Expression of FFAR3 and FFAR4 Is Increased in Gastroesophageal Reflux Disease
por: Fabisiak, Adam, et al.
Publicado: (2020)

Regulation of Energy Homeostasis via GPR120
por: Ichimura, Atsuhiko, et al.
Publicado: (2014)

Axon Guidance Molecules in the Islets of Langerhans
por: Waters, Bayley J., et al.
Publicado: (2022)

An Autonomous Cannabinoid System in Islets of Langerhans
por: Aseer, Kanikkai Raja, et al.
Publicado: (2021)

Lack of FFAR1/GPR40 Does Not Protect Mice From High-Fat Diet–Induced Metabolic Disease
por: Lan, Hong, et al.
Publicado: (2008)

Cloning, Identification and Functional Characterization of Bovine Free Fatty Acid Receptor-1 (FFAR1/GPR40) in Neutrophils
por: Manosalva, Carolina, et al.
Publicado: (2015)

FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice
por: Sadamura, Yuko, et al.
Publicado: (2021)

The Effects of Exendin-4 Treatment on Graft Failure: An Animal Study Using a Novel Re-Vascularized Minimal Human Islet Transplant Model
por: Sahraoui, Afaf, et al.
Publicado: (2015)

FFA4/GPR120: Pharmacology and Therapeutic Opportunities
por: Milligan, Graeme, et al.
Publicado: (2017)

GPR120 is an important inflammatory regulator in the development of osteoarthritis
por: Chen, Yuanfeng, et al.
Publicado: (2018)

The development of a GPR44 targeting radioligand [(11)C]AZ12204657 for in vivo assessment of beta cell mass
por: Jahan, Mahabuba, et al.
Publicado: (2018)

Purification of Islets of Langerhans from Porcine Pancreas
por: Graham, John
Publicado: (2002)

Geometric and topological characterization of the cytoarchitecture of islets of Langerhans
por: Aggarwal, Manu, et al.
Publicado: (2023)

Somatostatin receptors 2 and 5 are preferentially expressed in proliferating endothelium
por: Adams, R L, et al.
Publicado: (2005)

FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing
por: Ang, Zhiwei, et al.
Publicado: (2018)

Molecular characterization of free fatty acid receptors FFAR2 and FFAR3 in the domestic cat
por: Yamamoto, Ichiro, et al.
Publicado: (2020)

GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo
por: Hauge, Maria, et al.
Publicado: (2014)

Vascular, but not luminal, activation of FFAR1 (GPR40) stimulates GLP-1 secretion from isolated perfused rat small intestine
por: Christensen, Louise W, et al.
Publicado: (2015)

An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesis
por: Sivaprakasam, S, et al.
Publicado: (2016)

PT640. The dysfunction of brain free fatty acid receptor GPR40/FFAR1 signaling relate to the development of chronic pain
por: Nakamoto, Kazuo, et al.
Publicado: (2016)

PS04. The changes of emotional behavior in a free fatty acid receptor 1, GPR40/FFAR1, deficient mice
por: Aizawa, Fuka, et al.
Publicado: (2016)

Potential roles of GPR120 and its agonists in the management of diabetes
por: Zhang, Dan, et al.
Publicado: (2014)

GPR120 promotes neutrophil control of intestinal bacterial infection
por: Zhou, Zheng, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_15bqdmikj0ha5ve89ngjstt4ef