LINking microRNAs, kidney development, and Wilms tumors

In this issue of Genes & Development, Urbach and colleagues (pp. 971–982) provide compelling data suggesting a role for LIN28 in the pathogenesis of a significant percentage of Wilms tumors. These data extend our insights in the genetics underlying Wilms tumor development and emphasize the impor...

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Detalles Bibliográficos
Autores principales: Hohenstein, Peter, Hastie, Nicholas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018490/
https://www.ncbi.nlm.nih.gov/pubmed/24788514
http://dx.doi.org/10.1101/gad.242735.114
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author Hohenstein, Peter
Hastie, Nicholas D.
author_facet Hohenstein, Peter
Hastie, Nicholas D.
author_sort Hohenstein, Peter
collection PubMed
description In this issue of Genes & Development, Urbach and colleagues (pp. 971–982) provide compelling data suggesting a role for LIN28 in the pathogenesis of a significant percentage of Wilms tumors. These data extend our insights in the genetics underlying Wilms tumor development and emphasize the importance of stemness and microRNA-mediated processes in the origins of these tumors.
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spelling pubmed-40184902014-11-01 LINking microRNAs, kidney development, and Wilms tumors Hohenstein, Peter Hastie, Nicholas D. Genes Dev Perspective In this issue of Genes & Development, Urbach and colleagues (pp. 971–982) provide compelling data suggesting a role for LIN28 in the pathogenesis of a significant percentage of Wilms tumors. These data extend our insights in the genetics underlying Wilms tumor development and emphasize the importance of stemness and microRNA-mediated processes in the origins of these tumors. Cold Spring Harbor Laboratory Press 2014-05-01 /pmc/articles/PMC4018490/ /pubmed/24788514 http://dx.doi.org/10.1101/gad.242735.114 Text en © 2014 Hohenstein and Hastie; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Perspective
Hohenstein, Peter
Hastie, Nicholas D.
LINking microRNAs, kidney development, and Wilms tumors
title LINking microRNAs, kidney development, and Wilms tumors
title_full LINking microRNAs, kidney development, and Wilms tumors
title_fullStr LINking microRNAs, kidney development, and Wilms tumors
title_full_unstemmed LINking microRNAs, kidney development, and Wilms tumors
title_short LINking microRNAs, kidney development, and Wilms tumors
title_sort linking micrornas, kidney development, and wilms tumors
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018490/
https://www.ncbi.nlm.nih.gov/pubmed/24788514
http://dx.doi.org/10.1101/gad.242735.114
work_keys_str_mv AT hohensteinpeter linkingmicrornaskidneydevelopmentandwilmstumors
AT hastienicholasd linkingmicrornaskidneydevelopmentandwilmstumors

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