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Voxel-based morphometry analyses of in vivo MRI in the aging mouse lemur primate

Cerebral atrophy is one of the most widely brain alterations associated to aging. A clear relationship has been established between age-associated cognitive impairments and cerebral atrophy. The mouse lemur (Microcebus murinus) is a small primate used as a model of age-related neurodegenerative proc...

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Autores principales: Sawiak, Stephen J., Picq, Jean-Luc, Dhenain, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018531/
https://www.ncbi.nlm.nih.gov/pubmed/24834052
http://dx.doi.org/10.3389/fnagi.2014.00082
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author Sawiak, Stephen J.
Picq, Jean-Luc
Dhenain, Marc
author_facet Sawiak, Stephen J.
Picq, Jean-Luc
Dhenain, Marc
author_sort Sawiak, Stephen J.
collection PubMed
description Cerebral atrophy is one of the most widely brain alterations associated to aging. A clear relationship has been established between age-associated cognitive impairments and cerebral atrophy. The mouse lemur (Microcebus murinus) is a small primate used as a model of age-related neurodegenerative processes. It is the first non-human primate in which cerebral atrophy has been correlated with cognitive deficits. Previous studies of cerebral atrophy in this model were based on time consuming manual delineation or measurement of selected brain regions from magnetic resonance images (MRI). These measures could not be used to analyse regions that cannot be easily outlined such as the nucleus basalis of Meynert or the subiculum. In humans, morphometric assessment of structural changes with age is generally performed with automated procedures such as voxel-based morphometry (VBM). The objective of our work was to perform user-independent assessment of age-related morphological changes in the whole brain of large mouse lemur populations thanks to VBM. The study was based on the SPMMouse toolbox of SPM 8 and involved thirty mouse lemurs aged from 1.9 to 11.3 years. The automatic method revealed for the first time atrophy in regions where manual delineation is prohibitive (nucleus basalis of Meynert, subiculum, prepiriform cortex, Brodmann areas 13–16, hypothalamus, putamen, thalamus, corpus callosum). Some of these regions are described as particularly sensitive to age-associated alterations in humans. The method revealed also age-associated atrophy in cortical regions (cingulate, occipital, parietal), nucleus septalis, and the caudate. Manual measures performed in some of these regions were in good agreement with results from automatic measures. The templates generated in this study as well as the toolbox for SPM8 can be downloaded. These tools will be valuable for future evaluation of various treatments that are tested to modulate cerebral aging in lemurs.
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spelling pubmed-40185312014-05-15 Voxel-based morphometry analyses of in vivo MRI in the aging mouse lemur primate Sawiak, Stephen J. Picq, Jean-Luc Dhenain, Marc Front Aging Neurosci Neuroscience Cerebral atrophy is one of the most widely brain alterations associated to aging. A clear relationship has been established between age-associated cognitive impairments and cerebral atrophy. The mouse lemur (Microcebus murinus) is a small primate used as a model of age-related neurodegenerative processes. It is the first non-human primate in which cerebral atrophy has been correlated with cognitive deficits. Previous studies of cerebral atrophy in this model were based on time consuming manual delineation or measurement of selected brain regions from magnetic resonance images (MRI). These measures could not be used to analyse regions that cannot be easily outlined such as the nucleus basalis of Meynert or the subiculum. In humans, morphometric assessment of structural changes with age is generally performed with automated procedures such as voxel-based morphometry (VBM). The objective of our work was to perform user-independent assessment of age-related morphological changes in the whole brain of large mouse lemur populations thanks to VBM. The study was based on the SPMMouse toolbox of SPM 8 and involved thirty mouse lemurs aged from 1.9 to 11.3 years. The automatic method revealed for the first time atrophy in regions where manual delineation is prohibitive (nucleus basalis of Meynert, subiculum, prepiriform cortex, Brodmann areas 13–16, hypothalamus, putamen, thalamus, corpus callosum). Some of these regions are described as particularly sensitive to age-associated alterations in humans. The method revealed also age-associated atrophy in cortical regions (cingulate, occipital, parietal), nucleus septalis, and the caudate. Manual measures performed in some of these regions were in good agreement with results from automatic measures. The templates generated in this study as well as the toolbox for SPM8 can be downloaded. These tools will be valuable for future evaluation of various treatments that are tested to modulate cerebral aging in lemurs. Frontiers Media S.A. 2014-05-06 /pmc/articles/PMC4018531/ /pubmed/24834052 http://dx.doi.org/10.3389/fnagi.2014.00082 Text en Copyright © 2014 Sawiak, Picq and Dhenain. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Sawiak, Stephen J.
Picq, Jean-Luc
Dhenain, Marc
Voxel-based morphometry analyses of in vivo MRI in the aging mouse lemur primate
title Voxel-based morphometry analyses of in vivo MRI in the aging mouse lemur primate
title_full Voxel-based morphometry analyses of in vivo MRI in the aging mouse lemur primate
title_fullStr Voxel-based morphometry analyses of in vivo MRI in the aging mouse lemur primate
title_full_unstemmed Voxel-based morphometry analyses of in vivo MRI in the aging mouse lemur primate
title_short Voxel-based morphometry analyses of in vivo MRI in the aging mouse lemur primate
title_sort voxel-based morphometry analyses of in vivo mri in the aging mouse lemur primate
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018531/
https://www.ncbi.nlm.nih.gov/pubmed/24834052
http://dx.doi.org/10.3389/fnagi.2014.00082
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