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Understanding entangled cerebral networks: a prerequisite for restoring brain function with brain-computer interfaces

Historically, cerebral processing has been conceptualized as a framework based on statically localized functions. However, a growing amount of evidence supports a hodotopical (delocalized) and flexible organization. A number of studies have reported absence of a permanent neurological deficit after...

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Detalles Bibliográficos
Autores principales: Mandonnet, Emmanuel, Duffau, Hugues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018536/
https://www.ncbi.nlm.nih.gov/pubmed/24834030
http://dx.doi.org/10.3389/fnsys.2014.00082
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author Mandonnet, Emmanuel
Duffau, Hugues
author_facet Mandonnet, Emmanuel
Duffau, Hugues
author_sort Mandonnet, Emmanuel
collection PubMed
description Historically, cerebral processing has been conceptualized as a framework based on statically localized functions. However, a growing amount of evidence supports a hodotopical (delocalized) and flexible organization. A number of studies have reported absence of a permanent neurological deficit after massive surgical resections of eloquent brain tissue. These results highlight the tremendous plastic potential of the brain. Understanding anatomo-functional correlates underlying this cerebral reorganization is a prerequisite to restore brain functions through brain-computer interfaces (BCIs) in patients with cerebral diseases, or even to potentiate brain functions in healthy individuals. Here, we review current knowledge of neural networks that could be utilized in the BCIs that enable movements and language. To this end, intraoperative electrical stimulation in awake patients provides valuable information on the cerebral functional maps, their connectomics and plasticity. Overall, these studies indicate that the complex cerebral circuitry that underpins interactions between action, cognition and behavior should be throughly investigated before progress in BCI approaches can be achieved.
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spelling pubmed-40185362014-05-15 Understanding entangled cerebral networks: a prerequisite for restoring brain function with brain-computer interfaces Mandonnet, Emmanuel Duffau, Hugues Front Syst Neurosci Neuroscience Historically, cerebral processing has been conceptualized as a framework based on statically localized functions. However, a growing amount of evidence supports a hodotopical (delocalized) and flexible organization. A number of studies have reported absence of a permanent neurological deficit after massive surgical resections of eloquent brain tissue. These results highlight the tremendous plastic potential of the brain. Understanding anatomo-functional correlates underlying this cerebral reorganization is a prerequisite to restore brain functions through brain-computer interfaces (BCIs) in patients with cerebral diseases, or even to potentiate brain functions in healthy individuals. Here, we review current knowledge of neural networks that could be utilized in the BCIs that enable movements and language. To this end, intraoperative electrical stimulation in awake patients provides valuable information on the cerebral functional maps, their connectomics and plasticity. Overall, these studies indicate that the complex cerebral circuitry that underpins interactions between action, cognition and behavior should be throughly investigated before progress in BCI approaches can be achieved. Frontiers Media S.A. 2014-05-06 /pmc/articles/PMC4018536/ /pubmed/24834030 http://dx.doi.org/10.3389/fnsys.2014.00082 Text en Copyright © 2014 Mandonnet and Duffau. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Mandonnet, Emmanuel
Duffau, Hugues
Understanding entangled cerebral networks: a prerequisite for restoring brain function with brain-computer interfaces
title Understanding entangled cerebral networks: a prerequisite for restoring brain function with brain-computer interfaces
title_full Understanding entangled cerebral networks: a prerequisite for restoring brain function with brain-computer interfaces
title_fullStr Understanding entangled cerebral networks: a prerequisite for restoring brain function with brain-computer interfaces
title_full_unstemmed Understanding entangled cerebral networks: a prerequisite for restoring brain function with brain-computer interfaces
title_short Understanding entangled cerebral networks: a prerequisite for restoring brain function with brain-computer interfaces
title_sort understanding entangled cerebral networks: a prerequisite for restoring brain function with brain-computer interfaces
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018536/
https://www.ncbi.nlm.nih.gov/pubmed/24834030
http://dx.doi.org/10.3389/fnsys.2014.00082
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