Discovering up-regulated VEGF–C expression in swine umbilical vein endothelial cells by classical swine fever virus Shimen

Infection of domestic swine with the highly virulent Shimen strain of classical swine fever virus causes hemorrhagic lymphadenitis and diffuse hemorrhaging in infected swine. We analyzed patterns of gene expression for CSFV Shimen in swine umbilical vein endothelial cells (SUVECs). Transcription of...

Descripción completa

Detalles Bibliográficos
Autores principales: Ning, Pengbo, Zhang, Yanming, Guo, Kangkang, Chen, Ru, Liang, Wulong, Lin, Zhi, Li, Helin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018968/
https://www.ncbi.nlm.nih.gov/pubmed/24758593
http://dx.doi.org/10.1186/1297-9716-45-48
_version_ 1782480133412618240
author Ning, Pengbo
Zhang, Yanming
Guo, Kangkang
Chen, Ru
Liang, Wulong
Lin, Zhi
Li, Helin
author_facet Ning, Pengbo
Zhang, Yanming
Guo, Kangkang
Chen, Ru
Liang, Wulong
Lin, Zhi
Li, Helin
author_sort Ning, Pengbo
collection PubMed
description Infection of domestic swine with the highly virulent Shimen strain of classical swine fever virus causes hemorrhagic lymphadenitis and diffuse hemorrhaging in infected swine. We analyzed patterns of gene expression for CSFV Shimen in swine umbilical vein endothelial cells (SUVECs). Transcription of the vascular endothelial growth factor (VEGF) C gene (VEGF-C) and translation of the corresponding protein were significantly up-regulated in SUVECs. Our findings suggest that VEGF-C is involved in mechanisms of acute infection caused by virulent strains of CSFV.
format Online
Article
Text
id pubmed-4018968
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-40189682014-05-14 Discovering up-regulated VEGF–C expression in swine umbilical vein endothelial cells by classical swine fever virus Shimen Ning, Pengbo Zhang, Yanming Guo, Kangkang Chen, Ru Liang, Wulong Lin, Zhi Li, Helin Vet Res Short Report Infection of domestic swine with the highly virulent Shimen strain of classical swine fever virus causes hemorrhagic lymphadenitis and diffuse hemorrhaging in infected swine. We analyzed patterns of gene expression for CSFV Shimen in swine umbilical vein endothelial cells (SUVECs). Transcription of the vascular endothelial growth factor (VEGF) C gene (VEGF-C) and translation of the corresponding protein were significantly up-regulated in SUVECs. Our findings suggest that VEGF-C is involved in mechanisms of acute infection caused by virulent strains of CSFV. BioMed Central 2014 2014-04-23 /pmc/articles/PMC4018968/ /pubmed/24758593 http://dx.doi.org/10.1186/1297-9716-45-48 Text en Copyright © 2014 Ning et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Ning, Pengbo
Zhang, Yanming
Guo, Kangkang
Chen, Ru
Liang, Wulong
Lin, Zhi
Li, Helin
Discovering up-regulated VEGF–C expression in swine umbilical vein endothelial cells by classical swine fever virus Shimen
title Discovering up-regulated VEGF–C expression in swine umbilical vein endothelial cells by classical swine fever virus Shimen
title_full Discovering up-regulated VEGF–C expression in swine umbilical vein endothelial cells by classical swine fever virus Shimen
title_fullStr Discovering up-regulated VEGF–C expression in swine umbilical vein endothelial cells by classical swine fever virus Shimen
title_full_unstemmed Discovering up-regulated VEGF–C expression in swine umbilical vein endothelial cells by classical swine fever virus Shimen
title_short Discovering up-regulated VEGF–C expression in swine umbilical vein endothelial cells by classical swine fever virus Shimen
title_sort discovering up-regulated vegf–c expression in swine umbilical vein endothelial cells by classical swine fever virus shimen
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018968/
https://www.ncbi.nlm.nih.gov/pubmed/24758593
http://dx.doi.org/10.1186/1297-9716-45-48
work_keys_str_mv AT ningpengbo discoveringupregulatedvegfcexpressioninswineumbilicalveinendothelialcellsbyclassicalswinefevervirusshimen
AT zhangyanming discoveringupregulatedvegfcexpressioninswineumbilicalveinendothelialcellsbyclassicalswinefevervirusshimen
AT guokangkang discoveringupregulatedvegfcexpressioninswineumbilicalveinendothelialcellsbyclassicalswinefevervirusshimen
AT chenru discoveringupregulatedvegfcexpressioninswineumbilicalveinendothelialcellsbyclassicalswinefevervirusshimen
AT liangwulong discoveringupregulatedvegfcexpressioninswineumbilicalveinendothelialcellsbyclassicalswinefevervirusshimen
AT linzhi discoveringupregulatedvegfcexpressioninswineumbilicalveinendothelialcellsbyclassicalswinefevervirusshimen
AT lihelin discoveringupregulatedvegfcexpressioninswineumbilicalveinendothelialcellsbyclassicalswinefevervirusshimen

Ejemplares similares