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Transgenic zebrafish model of the C43G human insulin gene mutation

AIMS/INTRODUCTION: The human insulin gene/preproinsulin protein mutation C43G disrupts disulfide bond formation and causes diabetes in humans. Previous in vitro studies showed that these mutant proteins are retained in the endoplasmic reticulum (ER), are not secreted and are associated with decrease...

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Detalles Bibliográficos
Autores principales:	Eames, Stefani C, Kinkel, Mary D, Rajan, Sindhu, Prince, Victoria E, Philipson, Louis H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wiley-Blackwell 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019270/ https://www.ncbi.nlm.nih.gov/pubmed/24843647 http://dx.doi.org/10.1111/jdi.12015

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