Suicide HSVtk Gene Delivery by Neurotensin-Polyplex Nanoparticles via the Bloodstream and GCV Treatment Specifically Inhibit the Growth of Human MDA-MB-231 Triple Negative Breast Cancer Tumors Xenografted in Athymic Mice

The human breast adenocarcinoma cell line MDA-MB-231 has the triple-negative breast cancer (TNBC) phenotype, which is an aggressive subtype with no specific treatment. MDA-MB-231 cells express neurotensin receptor type 1 (NTSR1), which makes these cells an attractive target of therapeutic genes that...

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Detalles Bibliográficos
Autores principales: Castillo-Rodríguez, Rosa A., Arango-Rodríguez, Martha L., Escobedo, Lourdes, Hernandez-Baltazar, Daniel, Gompel, Anne, Forgez, Patricia, Martínez-Fong, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019532/
https://www.ncbi.nlm.nih.gov/pubmed/24824754
http://dx.doi.org/10.1371/journal.pone.0097151

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