A Note on Exact Differences between Beta Distributions in Genomic (Methylation) Studies

We apply a known algorithm for computing exactly inequalities between Beta distributions to assess whether a given position in a genome is differentially methylated across samples. We discuss the advantages brought by the adoption of this solution with respect to two approximations (Fisher's te...

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Detalles Bibliográficos
Autores principales: Raineri, Emanuele, Dabad, Marc, Heath, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019606/
https://www.ncbi.nlm.nih.gov/pubmed/24824426
http://dx.doi.org/10.1371/journal.pone.0097349
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author Raineri, Emanuele
Dabad, Marc
Heath, Simon
author_facet Raineri, Emanuele
Dabad, Marc
Heath, Simon
author_sort Raineri, Emanuele
collection PubMed
description We apply a known algorithm for computing exactly inequalities between Beta distributions to assess whether a given position in a genome is differentially methylated across samples. We discuss the advantages brought by the adoption of this solution with respect to two approximations (Fisher's test and Z score). The same formalism presented here can be applied in a similar way to variant calling.
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spelling pubmed-40196062014-05-16 A Note on Exact Differences between Beta Distributions in Genomic (Methylation) Studies Raineri, Emanuele Dabad, Marc Heath, Simon PLoS One Research Article We apply a known algorithm for computing exactly inequalities between Beta distributions to assess whether a given position in a genome is differentially methylated across samples. We discuss the advantages brought by the adoption of this solution with respect to two approximations (Fisher's test and Z score). The same formalism presented here can be applied in a similar way to variant calling. Public Library of Science 2014-05-13 /pmc/articles/PMC4019606/ /pubmed/24824426 http://dx.doi.org/10.1371/journal.pone.0097349 Text en © 2014 Raineri et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Raineri, Emanuele
Dabad, Marc
Heath, Simon
A Note on Exact Differences between Beta Distributions in Genomic (Methylation) Studies
title A Note on Exact Differences between Beta Distributions in Genomic (Methylation) Studies
title_full A Note on Exact Differences between Beta Distributions in Genomic (Methylation) Studies
title_fullStr A Note on Exact Differences between Beta Distributions in Genomic (Methylation) Studies
title_full_unstemmed A Note on Exact Differences between Beta Distributions in Genomic (Methylation) Studies
title_short A Note on Exact Differences between Beta Distributions in Genomic (Methylation) Studies
title_sort note on exact differences between beta distributions in genomic (methylation) studies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019606/
https://www.ncbi.nlm.nih.gov/pubmed/24824426
http://dx.doi.org/10.1371/journal.pone.0097349
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