Toll-Like Receptor 4 Mutant and Null Mice Retain Morphine-Induced Tolerance, Hyperalgesia, and Physical Dependence

The innate immune system modulates opioid-induced effects within the central nervous system and one target that has received considerable attention is the toll-like receptor 4 (TLR4). Here, we examined the contribution of TLR4 in the development of morphine tolerance, hyperalgesia, and physical depe...

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Detalles Bibliográficos
Autores principales: Mattioli, Theresa Alexandra, Leduc-Pessah, Heather, Skelhorne-Gross, Graham, Nicol, Christopher J. B., Milne, Brian, Trang, Tuan, Cahill, Catherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019634/
https://www.ncbi.nlm.nih.gov/pubmed/24824631
http://dx.doi.org/10.1371/journal.pone.0097361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019634/
https://www.ncbi.nlm.nih.gov/pubmed/24824631
http://dx.doi.org/10.1371/journal.pone.0097361

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